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2a72

From Proteopedia

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[[Image:2a72.gif|left|200px]]
 
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{{Structure
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==Structure of the regulator of G-protein signaling domain of RGS7==
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|PDB= 2a72 |SIZE=350|CAPTION= <scene name='initialview01'>2a72</scene>, resolution 2.00&Aring;
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<StructureSection load='2a72' size='340' side='right'caption='[[2a72]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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<table><tr><td colspan='2'>[[2a72]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2A72 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [https://pdbe.org/2a72 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB], [https://www.ebi.ac.uk/pdbsum/2a72 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2a72 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2a72 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2a72 OCA], [http://www.ebi.ac.uk/pdbsum/2a72 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2a72 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/RGS7_HUMAN RGS7_HUMAN] Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a7/2a72_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2a72 ConSurf].
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<div style="clear:both"></div>
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'''Structure of the regulator of G-protein signaling domain of RGS7'''
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==See Also==
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*[[Regulator of G-protein signaling 3D structures|Regulator of G-protein signaling 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2A72 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A72 OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F von.]]
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[[Category: Doyle DA]]
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[[Category: Doyle, D A.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J M.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Johansson C]]
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[[Category: Johansson, C.]]
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[[Category: Phillips C]]
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[[Category: Phillips, C.]]
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[[Category: Schoch GA]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Smee C]]
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[[Category: Schoch, G A.]]
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[[Category: Sundstrom M]]
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[[Category: Smee, C.]]
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[[Category: Von Delft F]]
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[[Category: Sundstrom, M.]]
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[[Category: gtpase-activating proteins (gap)]]
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[[Category: human rgs7]]
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[[Category: regulator of g-protein signaling 7]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 01:48:43 2008''
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Current revision

Structure of the regulator of G-protein signaling domain of RGS7

PDB ID 2a72

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