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2aee

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[[Image:2aee.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes==
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|PDB= 2aee |SIZE=350|CAPTION= <scene name='initialview01'>2aee</scene>, resolution 1.95&Aring;
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<StructureSection load='2aee' size='340' side='right'caption='[[2aee]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2aee]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AEE FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Orotate_phosphoribosyltransferase Orotate phosphoribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.10 2.4.2.10]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= pyrE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1314 Streptococcus pyogenes])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aee OCA], [https://pdbe.org/2aee PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aee RCSB], [https://www.ebi.ac.uk/pdbsum/2aee PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aee ProSAT], [https://www.topsan.org/Proteins/MCSG/2aee TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PYRE_STRP1 PYRE_STRP1] Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ae/2aee_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aee ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes'''
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==See Also==
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*[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2AEE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AEE OCA].
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[[Category: Large Structures]]
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[[Category: Orotate phosphoribosyltransferase]]
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[[Category: Single protein]]
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[[Category: Streptococcus pyogenes]]
[[Category: Streptococcus pyogenes]]
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[[Category: Chang, C.]]
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[[Category: Chang C]]
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[[Category: Collart, F.]]
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[[Category: Collart F]]
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[[Category: Joachimiak, A.]]
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[[Category: Joachimiak A]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: MCSG, Midwest Center for Structural Genomics.]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: SO4]]
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[[Category: mcsg]]
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[[Category: midwest center for structural genomic]]
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[[Category: orotate phosphoribosyltransferase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:48:37 2008''
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Current revision

Crystal structure of Orotate phosphoribosyltransferase from Streptococcus pyogenes

PDB ID 2aee

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