2aie

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[[Image:2aie.png|left|200px]]
 
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{{STRUCTURE_2aie| PDB=2aie | SCENE= }}
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==S.pneumoniae polypeptide deformylase complexed with SB-505684==
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<StructureSection load='2aie' size='340' side='right'caption='[[2aie]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===S.pneumoniae polypeptide deformylase complexed with SB-505684===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2aie]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AIE FirstGlance]. <br>
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{{ABSTRACT_PUBMED_12538898}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SB9:HYDROXY[3-(6-METHYLPYRIDIN-2-YL)PROPYL]FORMAMIDE'>SB9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2aie FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2aie OCA], [https://pdbe.org/2aie PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2aie RCSB], [https://www.ebi.ac.uk/pdbsum/2aie PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2aie ProSAT]</span></td></tr>
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[[2aie]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AIE OCA].
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</table>
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== Function ==
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==Reference==
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[https://www.uniprot.org/uniprot/DEF_STRR6 DEF_STRR6] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity).
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<ref group="xtra">PMID:012538898</ref><references group="xtra"/>
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== Evolutionary Conservation ==
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[[Category: Peptide deformylase]]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ai/2aie_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2aie ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptococcus pneumoniae]]
[[Category: Streptococcus pneumoniae]]
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[[Category: Aubart, K.]]
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[[Category: Aubart K]]
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[[Category: Christensen, S B.]]
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[[Category: Christensen SB]]
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[[Category: Fosberry, A.]]
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[[Category: Fosberry A]]
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[[Category: Jones, J.]]
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[[Category: Jones J]]
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[[Category: Lewis, C.]]
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[[Category: Lewis C]]
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[[Category: Lonetto, M.]]
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[[Category: Lonetto M]]
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[[Category: McManus, E.]]
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[[Category: McManus E]]
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[[Category: Petit, C M.]]
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[[Category: Petit CM]]
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[[Category: Smith, K J.]]
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[[Category: Smith KJ]]
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[[Category: Smyth, M.]]
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[[Category: Smyth M]]
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[[Category: Hydrolase]]
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Current revision

S.pneumoniae polypeptide deformylase complexed with SB-505684

PDB ID 2aie

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