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2ano

From Proteopedia

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[[Image:2ano.png|left|200px]]
 
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{{STRUCTURE_2ano| PDB=2ano | SCENE= }}
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==Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17==
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<StructureSection load='2ano' size='340' side='right'caption='[[2ano]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
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===Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2ano]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2ANO FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17125251}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=817:1-{[N-(1-IMINO-GUANIDINO-METHYL)]SULFANYLMETHYL}-3-TRIFLUOROMETHYL-BENZENE'>817</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ano FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ano OCA], [https://pdbe.org/2ano PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ano RCSB], [https://www.ebi.ac.uk/pdbsum/2ano PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ano ProSAT]</span></td></tr>
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[[2ano]] is a 1 chain structure of [[Dihydrofolate reductase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ANO OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DYR_ECOLI DYR_ECOLI] Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/an/2ano_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ano ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Dihydrofolate reductase|Dihydrofolate reductase]]
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*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017125251</ref><ref group="xtra">PMID:016126221</ref><references group="xtra"/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Brown, E D.]]
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[[Category: Large Structures]]
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[[Category: Daigle, D M.]]
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[[Category: Brown ED]]
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[[Category: Hughes, D W.]]
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[[Category: Daigle DM]]
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[[Category: Jackson, S G.]]
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[[Category: Hughes DW]]
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[[Category: Junop, M S.]]
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[[Category: Jackson SG]]
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[[Category: Mayer, S.]]
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[[Category: Junop MS]]
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[[Category: Organ, M.]]
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[[Category: Mayer S]]
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[[Category: Summerfield, R L.]]
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[[Category: Organ M]]
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[[Category: Dhfr]]
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[[Category: Summerfield RL]]
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[[Category: Oxidoreductase]]
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[[Category: Protein inhibitor complex]]
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Current revision

Crystal structure of E.coli dihydrofolate reductase in complex with NADPH and the inhibitor MS-SH08-17

PDB ID 2ano

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