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2azp

From Proteopedia

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(New page: 200px<br /><applet load="2azp" size="350" color="white" frame="true" align="right" spinBox="true" caption="2azp, resolution 2.13&Aring;" /> '''Crystal Structure of...)
Current revision (09:14, 14 February 2024) (edit) (undo)
 
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[[Image:2azp.gif|left|200px]]<br /><applet load="2azp" size="350" color="white" frame="true" align="right" spinBox="true"
 
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caption="2azp, resolution 2.13&Aring;" />
 
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'''Crystal Structure of PA1268 Solved by Sulfur SAD'''<br />
 
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==About this Structure==
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==Crystal Structure of PA1268 Solved by Sulfur SAD==
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2AZP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZP OCA].
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<StructureSection load='2azp' size='340' side='right'caption='[[2azp]], [[Resolution|resolution]] 2.13&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2azp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2AZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2AZP FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.13&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2azp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2azp OCA], [https://pdbe.org/2azp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2azp RCSB], [https://www.ebi.ac.uk/pdbsum/2azp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2azp ProSAT], [https://www.topsan.org/Proteins/MCSG/2azp TOPSAN]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/4HYPE_PSEAE 4HYPE_PSEAE] Allows intracellular utilization of 4-hydroxyproline, one of the major constituents of host collagen, by converting trans-4-hydroxy-L-proline (t4LHyp) to cis-4-hydroxy-D-proline (c4DHyp), which can be further metabolized by intracellular 4-hydroxy-D-proline oxidases. Strong B-cell mitogen. Plays an important role in the regulation of intra- and extracellular amino acid pools, allowing the bacterium to profit from host precursors and enzymatic pathways. Cannot use L-proline, trans-3-hydroxy-L-proline (t3LHyp) and pyrrolidone-5-carboxylate (P5C) as substrate.<ref>PMID:17849014</ref> <ref>PMID:20665524</ref> <ref>PMID:24980702</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/az/2azp_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2azp ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Pseudomonas aeruginosa]]
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[[Category: Single protein]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Gorodichtchenskaia E]]
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[[Category: Gorodichtchenskaia, E.]]
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[[Category: Joachimiak A]]
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[[Category: Joachimiak, A.]]
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[[Category: Liu Y]]
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[[Category: Liu, Y.]]
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[[Category: Pai EF]]
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[[Category: MCSG, Midwest.Center.for.Structural.Genomics.]]
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[[Category: Savchenko A]]
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[[Category: Pai, E.F.]]
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[[Category: Skarina T]]
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[[Category: Savchenko, A.]]
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[[Category: Yang C]]
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[[Category: Skarina, T.]]
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[[Category: Yang, C.]]
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[[Category: apc5861]]
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[[Category: mcsg]]
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[[Category: midwest center for structural genomics]]
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[[Category: pa1268]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomics]]
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[[Category: sulfur sad]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 18:13:18 2008''
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Current revision

Crystal Structure of PA1268 Solved by Sulfur SAD

PDB ID 2azp

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