2b51

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{{STRUCTURE_2b51| PDB=2b51 | SCENE= }}
 
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===Structural Basis for UTP Specificity of RNA Editing TUTases from Trypanosoma Brucei===
 
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{{ABSTRACT_PUBMED_16281058}}
 
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==About this Structure==
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==Structural Basis for UTP Specificity of RNA Editing TUTases from Trypanosoma Brucei==
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[[2b51]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B51 OCA].
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<StructureSection load='2b51' size='340' side='right'caption='[[2b51]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2b51]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei Trypanosoma brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2B51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2B51 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UTP:URIDINE+5-TRIPHOSPHATE'>UTP</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2b51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2b51 OCA], [https://pdbe.org/2b51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2b51 RCSB], [https://www.ebi.ac.uk/pdbsum/2b51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2b51 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TUT2_TRYBB TUT2_TRYBB] Terminal uridylyltransferase which, as part of the mitochondrial RNA editing core complex (RECC), is involved in the post-transcriptional editing of mitochondrial RNA, a process involving the addition and deletion of uridine (U) nucleotides in the pre-mRNA (PubMed:12820966, PubMed:19465686, PubMed:20362585). Specifically, catalyzes the addition of one U to single-stranded RNA with a preference for a 3'-terminal A or G and adds the number of Us specified by a guide RNA (gRNA) to precleaved double-stranded RNA editing substrates (PubMed:12820966, PubMed:19465686, PubMed:20362585, PubMed:16281058). Essential for the survival of the bloodstream form (PubMed:16281058).<ref>PMID:12820966</ref> <ref>PMID:16281058</ref> <ref>PMID:19465686</ref> <ref>PMID:20362585</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/b5/2b51_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2b51 ConSurf].
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<div style="clear:both"></div>
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==Reference==
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==See Also==
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<ref group="xtra">PMID:016281058</ref><references group="xtra"/><references/>
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*[[RNA uridylyltransferase|RNA uridylyltransferase]]
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[[Category: Trypanosoma brucei]]
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== References ==
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[[Category: Deng, J.]]
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<references/>
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[[Category: Ernst, N L.]]
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__TOC__
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[[Category: Hol, W G.]]
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</StructureSection>
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[[Category: Stuart, K D.]]
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[[Category: Large Structures]]
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[[Category: Turley, S.]]
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[[Category: Crystal structure]]
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[[Category: Editosome]]
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[[Category: Rna editing]]
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[[Category: Tbret2]]
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[[Category: Terminal uridylyl transferase]]
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[[Category: Transferase-rna binding protein complex]]
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[[Category: Trypanosoma brucei]]
[[Category: Trypanosoma brucei]]
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[[Category: Deng J]]
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[[Category: Ernst NL]]
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[[Category: Hol WG]]
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[[Category: Stuart KD]]
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[[Category: Turley S]]

Current revision

Structural Basis for UTP Specificity of RNA Editing TUTases from Trypanosoma Brucei

PDB ID 2b51

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