2bbv

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{{Seed}}
 
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[[Image:2bbv.png|left|200px]]
 
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==THE REFINED THREE-DIMENSIONAL STRUCTURE OF AN INSECT VIRUS AT 2.8 ANGSTROMS RESOLUTION==
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The line below this paragraph, containing "STRUCTURE_2bbv", creates the "Structure Box" on the page.
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<StructureSection load='2bbv' size='340' side='right'caption='[[2bbv]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bbv]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Black_beetle_virus Black beetle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBV FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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{{STRUCTURE_2bbv| PDB=2bbv | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbv OCA], [https://pdbe.org/2bbv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbv RCSB], [https://www.ebi.ac.uk/pdbsum/2bbv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CAPSD_BBV CAPSD_BBV] Capsid protein alpha self-assembles to form an icosahedral procapsid with a T=3 symmetry, about 30 nm in diameter, and consisting of 60 capsid proteins trimers. In addition, calcium ions are incorporated per capsid during assembly. The capsid encapsulates the two genomic RNAs. Capsid maturation occurs via autoproteolytic cleavage of capsid protein alpha generating capsid protein beta and the membrane-active peptide gamma (By similarity). Peptide gamma is a membrane-disrupting peptide produced by virus maturation, thereby creating the infectious virion. After penetration into the host cell, peptide gamma is probably exposed/released in endosomes, where it disrupts the endosomal membrane, facilitating translocation of viral RNA into the cytoplasm (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbv ConSurf].
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<div style="clear:both"></div>
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===THE REFINED THREE-DIMENSIONAL STRUCTURE OF AN INSECT VIRUS AT 2.8 ANGSTROMS RESOLUTION===
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==See Also==
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 8289282 is the PubMed ID number.
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{{ABSTRACT_PUBMED_8289282}}
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==About this Structure==
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2BBV is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Black_beetle_virus Black beetle virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBV OCA].
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==Reference==
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The refined three-dimensional structure of an insect virus at 2.8 A resolution., Wery JP, Reddy VS, Hosur MV, Johnson JE, J Mol Biol. 1994 Jan 14;235(2):565-86. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8289282 8289282]
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[[Category: Black beetle virus]]
[[Category: Black beetle virus]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Hosur, M V.]]
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[[Category: Hosur MV]]
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[[Category: Johnson, J E.]]
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[[Category: Johnson JE]]
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[[Category: Reddy, V S.]]
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[[Category: Reddy VS]]
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[[Category: Wery, J P.]]
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[[Category: Wery J-P]]
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[[Category: Double helix]]
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[[Category: Icosahedral virus]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:20:02 2008''
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Current revision

THE REFINED THREE-DIMENSIONAL STRUCTURE OF AN INSECT VIRUS AT 2.8 ANGSTROMS RESOLUTION

PDB ID 2bbv

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