2bbz

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{{Seed}}
 
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[[Image:2bbz.png|left|200px]]
 
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==Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition==
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The line below this paragraph, containing "STRUCTURE_2bbz", creates the "Structure Box" on the page.
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<StructureSection load='2bbz' size='340' side='right'caption='[[2bbz]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2bbz]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BBZ FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bbz OCA], [https://pdbe.org/2bbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bbz RCSB], [https://www.ebi.ac.uk/pdbsum/2bbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bbz ProSAT]</span></td></tr>
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{{STRUCTURE_2bbz| PDB=2bbz | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition===
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[https://www.uniprot.org/uniprot/CFLA_MCV1 CFLA_MCV1] Inhibits TNFRSF1A, TNFRSF6 and TNFRSF12 induced apoptosis. May interfere with caspase-8 recruitment and activation at the death-inducing signaling complex (DISC). May lead to higher virus production and contribute to virus persistence and oncogenicity.<ref>PMID:9087414</ref> <ref>PMID:9037025</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_16364918}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16364918 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bb/2bbz_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16364918}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bbz ConSurf].
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2BBZ is a 4 chains structure of sequences from [http://en.wikipedia.org/wiki/Molluscum_contagiosum_virus_subtype_1 Molluscum contagiosum virus subtype 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BBZ OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16364918</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Molluscum contagiosum virus subtype 1]]
[[Category: Molluscum contagiosum virus subtype 1]]
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[[Category: Ahmed, M.]]
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[[Category: Ahmed M]]
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[[Category: Lenardo, M J.]]
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[[Category: Lenardo MJ]]
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[[Category: Wan, F.]]
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[[Category: Wan F]]
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[[Category: Wang, L.]]
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[[Category: Wang L]]
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[[Category: Wu, H.]]
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[[Category: Wu H]]
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[[Category: Yang, J K.]]
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[[Category: Yang JK]]
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[[Category: Zheng, L.]]
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[[Category: Zheng L]]
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[[Category: Death effector domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 13:04:00 2009''
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Current revision

Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and vFLIP Inhibition

PDB ID 2bbz

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