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2dyn

From Proteopedia

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(New page: 200px<br /> <applet load="2dyn" size="450" color="white" frame="true" align="right" spinBox="true" caption="2dyn, resolution 2.30&Aring;" /> '''DYNAMIN (PLECKSTRIN...)
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[[Image:2dyn.gif|left|200px]]<br />
 
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<applet load="2dyn" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2dyn, resolution 2.30&Aring;" />
 
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'''DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)'''<br />
 
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==Overview==
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==DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)==
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The pleckstrin homology (PH) domain is a conserved module present in many, signal transducing and cytoskeletal proteins. Here we report the 2.8 A, crystal structure of the PH domain from dynamin. This domain consists of, seven beta-strands forming two roughly orthogonal antiparallel beta-sheets, terminating with an amphipathic alpha-helix. The structure also reveals a, non-covalent dimeric association of the PH domain and a hydrophobic pocket, surrounded by a charged rim. The dynamin PH domain structure is discussed, in relation to its potential role in mediating interactions between, proteins.
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<StructureSection load='2dyn' size='340' side='right'caption='[[2dyn]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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== Structural highlights ==
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==Disease==
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<table><tr><td colspan='2'>[[2dyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2DYN FirstGlance]. <br>
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Known diseases associated with this structure: Charcot-Marie-Tooth disease, dominant intermediate B OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602378 602378]], Myopathy, centronuclear OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602378 602378]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2dyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2dyn OCA], [https://pdbe.org/2dyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2dyn RCSB], [https://www.ebi.ac.uk/pdbsum/2dyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2dyn ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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2DYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2DYN OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/DYN1_HUMAN DYN1_HUMAN] Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes. Involved in receptor-mediated endocytosis.
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==Reference==
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== Evolutionary Conservation ==
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Crystal structure of the pleckstrin homology domain from dynamin., Timm D, Salim K, Gout I, Guruprasad L, Waterfield M, Blundell T, Nat Struct Biol. 1994 Nov;1(11):782-8. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7634088 7634088]
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dy/2dyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2dyn ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Timm, D.E.]]
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[[Category: Timm DE]]
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[[Category: motor protein]]
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[[Category: phospholipid binding]]
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[[Category: protein binding]]
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[[Category: signal transduction]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 21:40:58 2007''
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Current revision

DYNAMIN (PLECKSTRIN HOMOLOGY DOMAIN) (DYNPH)

PDB ID 2dyn

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