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2f23

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{{Seed}}
 
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[[Image:2f23.png|left|200px]]
 
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==Crystal structure of GreA factor homolog 1 (Gfh1) protein of Thermus thermophilus==
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The line below this paragraph, containing "STRUCTURE_2f23", creates the "Structure Box" on the page.
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<StructureSection load='2f23' size='340' side='right'caption='[[2f23]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB27 Thermus thermophilus HB27]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F23 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f23 OCA], [https://pdbe.org/2f23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f23 RCSB], [https://www.ebi.ac.uk/pdbsum/2f23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f23 ProSAT]</span></td></tr>
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{{STRUCTURE_2f23| PDB=2f23 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of GreA factor homolog 1 (Gfh1) protein of Thermus thermophilus===
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[https://www.uniprot.org/uniprot/GFH1_THET2 GFH1_THET2] Inhibits all catalytic activities of RNA polymerase (RNAP) by partially occluding its substrate-binding site and preventing NTP binding.<ref>PMID:16628221</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 16628221 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f23_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_16628221}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f23 ConSurf].
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2F23 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F23 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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pH-dependent conformational switch activates the inhibitor of transcription elongation., Laptenko O, Kim SS, Lee J, Starodubtseva M, Cava F, Berenguer J, Kong XP, Borukhov S, EMBO J. 2006 May 17;25(10):2131-41. Epub 2006 Apr 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16628221 16628221]
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__TOC__
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[[Category: Single protein]]
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</StructureSection>
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[[Category: Thermus thermophilus]]
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[[Category: Large Structures]]
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[[Category: Kim, S S.]]
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[[Category: Thermus thermophilus HB27]]
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[[Category: Kong, X P.]]
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[[Category: Kim S-S]]
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[[Category: Crystal structure anti-grea gfh1 thermus thermophilus]]
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[[Category: Kong XP]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:18:01 2008''
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Current revision

Crystal structure of GreA factor homolog 1 (Gfh1) protein of Thermus thermophilus

PDB ID 2f23

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