This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2f2c

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:21, 14 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2f2c.png|left|200px]]
 
-
<!--
+
==X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol==
-
The line below this paragraph, containing "STRUCTURE_2f2c", creates the "Structure Box" on the page.
+
<StructureSection load='2f2c' size='340' side='right'caption='[[2f2c]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2f2c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Herpesvirus_saimiri_(strain_11) Herpesvirus saimiri (strain 11)] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F2C FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP9:(2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL'>AP9</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
{{STRUCTURE_2f2c| PDB=2f2c | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f2c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f2c OCA], [https://pdbe.org/2f2c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f2c RCSB], [https://www.ebi.ac.uk/pdbsum/2f2c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f2c ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/CGH2_SHV21 CGH2_SHV21] May be highly relevant to the process of cellular transformation and rapid T-cell proliferation effected by HVS during latent infections of T-cells in susceptible hosts.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f2/2f2c_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f2c ConSurf].
 +
<div style="clear:both"></div>
-
===X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol===
+
==See Also==
-
 
+
*[[Cyclin 3D structures|Cyclin 3D structures]]
-
 
+
*[[Cyclin-dependent kinase 3D structures|Cyclin-dependent kinase 3D structures]]
-
<!--
+
__TOC__
-
The line below this paragraph, {{ABSTRACT_PUBMED_16789739}}, adds the Publication Abstract to the page
+
</StructureSection>
-
(as it appears on PubMed at http://www.pubmed.gov), where 16789739 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_16789739}}
+
-
 
+
-
==About this Structure==
+
-
2F2C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Saimiriine_herpesvirus_2 Saimiriine herpesvirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F2C OCA].
+
-
 
+
-
==Reference==
+
-
Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition., Lu H, Schulze-Gahmen U, J Med Chem. 2006 Jun 29;49(13):3826-31. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16789739 16789739]
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Non-specific serine/threonine protein kinase]]
+
[[Category: Large Structures]]
-
[[Category: Protein complex]]
+
[[Category: Lu H]]
-
[[Category: Saimiriine herpesvirus 2]]
+
[[Category: Schulze-Gahmen U]]
-
[[Category: Lu, H.]]
+
-
[[Category: Schulze-Gahmen, U]]
+
-
[[Category: Small molecule inhibitor bound between n-terminal and c-terminal domain of kinase]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:17:03 2008''
+

Current revision

X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol

PDB ID 2f2c

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f2c"
Personal tools