This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2f4u

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
(New page: 200px<br /><applet load="2f4u" size="350" color="white" frame="true" align="right" spinBox="true" caption="2f4u, resolution 2.600&Aring;" /> '''Asite RNA + designe...)
Current revision (09:21, 14 February 2024) (edit) (undo)
 
(14 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2f4u.gif|left|200px]]<br /><applet load="2f4u" size="350" color="white" frame="true" align="right" spinBox="true"
 
-
caption="2f4u, resolution 2.600&Aring;" />
 
-
'''Asite RNA + designer antibiotic'''<br />
 
-
==Overview==
+
==Asite RNA + designer antibiotic==
-
The X-ray crystal structures for the complexes of three designer, antibiotics, compounds 1, 2, and 3, bound to two models for the ribosomal, aminoacyl-tRNA site (A site) at 2.5-3.0 Angstroms resolution and that of, neamine at 2.8 Angstroms resolution are described. Furthermore, the, complex of antibiotic 1 bound to the A site in the entire 30S ribosomal, subunit of Thermus thermophilus is reported at 3.8 Angstroms resolution., Molecular dynamics simulations revealed that the designer compounds, provide additional stability to bases A1492 and A1493 in their, extrahelical forms. Snapshots from the simulations were used for free, energy calculations, which revealed that van der Waals and hydrophobic, effects were the driving forces behind the binding of designer antibiotic, 3 when compared to the parental neamine.
+
<StructureSection load='2f4u' size='340' side='right'caption='[[2f4u]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-
 
+
== Structural highlights ==
-
==About this Structure==
+
<table><tr><td colspan='2'>[[2f4u]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F4U FirstGlance]. <br>
-
2F4U is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=AB6:'>AB6</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4U OCA].
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
-
 
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AB6:(2R)-4-AMINO-N-((1R,2S,3R,4R,5S)-5-AMINO-4-[(2-AMINO-2-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-{2-[(3-AMINOPROPYL)AMINO]ETHOXY}-3-HYDROXYCYCLOHEXYL)-2-HYDROXYBUTANAMIDE'>AB6</scene></td></tr>
-
==Reference==
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f4u OCA], [https://pdbe.org/2f4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f4u RCSB], [https://www.ebi.ac.uk/pdbsum/2f4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f4u ProSAT]</span></td></tr>
-
Interactions of designer antibiotics and the bacterial ribosomal aminoacyl-tRNA site., Murray JB, Meroueh SO, Russell RJ, Lentzen G, Haddad J, Mobashery S, Chem Biol. 2006 Feb;13(2):129-38. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16492561 16492561]
+
</table>
-
[[Category: Protein complex]]
+
__TOC__
-
[[Category: Haddad, J.]]
+
</StructureSection>
-
[[Category: Lentzen, G.]]
+
[[Category: Large Structures]]
-
[[Category: Meroueh, S.O.]]
+
[[Category: Haddad J]]
-
[[Category: Mobashery, S.]]
+
[[Category: Lentzen G]]
-
[[Category: Murray, J.B.]]
+
[[Category: Meroueh SO]]
-
[[Category: Russell, R.J.]]
+
[[Category: Mobashery S]]
-
[[Category: AB6]]
+
[[Category: Murray JB]]
-
[[Category: asite rna]]
+
[[Category: Russell RJ]]
-
[[Category: designer antibiotic]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jan 29 19:27:36 2008''
+

Current revision

Asite RNA + designer antibiotic

PDB ID 2f4u

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2f4u"
Personal tools