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2f7n

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[[Image:2f7n.png|left|200px]]
 
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==Structure of D. radiodurans Dps-1==
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The line below this paragraph, containing "STRUCTURE_2f7n", creates the "Structure Box" on the page.
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<StructureSection load='2f7n' size='340' side='right'caption='[[2f7n]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f7n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F7N FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2f7n| PDB=2f7n | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f7n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f7n OCA], [https://pdbe.org/2f7n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f7n RCSB], [https://www.ebi.ac.uk/pdbsum/2f7n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f7n ProSAT]</span></td></tr>
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</table>
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===Structure of D. radiodurans Dps-1===
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== Function ==
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[https://www.uniprot.org/uniprot/DPS1_DEIRA DPS1_DEIRA] Protects DNA from oxidative damage by sequestering intracellular Fe(2+) ion and storing it in the form of Fe(3+) oxyhydroxide mineral. One hydrogen peroxide oxidizes two Fe(2+) ions, which prevents hydroxyl radical production by the Fenton reaction (By similarity). Both oligomeric forms of dps exhibit ferroxidase activity and DNA binding. Dodecameric dps is capable of Fe(2+) oxidation/mineralization. Only dimeric dps affords efficient DNA protection against hydroxyl radical-mediated cleavage.<ref>PMID:15755446</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16828801}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16828801 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f7/2f7n_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16828801}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2f7n]] is a 1 chain structure of [[Ferritin]] with sequence from [http://en.wikipedia.org/wiki/Deinococcus_radiodurans Deinococcus radiodurans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F7N OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f7n ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Ferritin]]
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*[[Ferritin 3D structures|Ferritin 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:16828801</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Deinococcus radiodurans]]
[[Category: Deinococcus radiodurans]]
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[[Category: Bhattacharyya, G.]]
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[[Category: Large Structures]]
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[[Category: Grove, A.]]
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[[Category: Bhattacharyya G]]
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[[Category: Kim, S G.]]
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[[Category: Grove A]]
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[[Category: Lee, Y H.]]
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[[Category: Kim SG]]
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[[Category: 4-helix bundle]]
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[[Category: Lee YH]]
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[[Category: Dna binding protein]]
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Current revision

Structure of D. radiodurans Dps-1

PDB ID 2f7n

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