2f8c

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{{Seed}}
 
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[[Image:2f8c.png|left|200px]]
 
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==Crystal structure of FPPS in complex with Zoledronate==
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The line below this paragraph, containing "STRUCTURE_2f8c", creates the "Structure Box" on the page.
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<StructureSection load='2f8c' size='340' side='right'caption='[[2f8c]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2f8c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2F8C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=ZOL:ZOLEDRONIC+ACID'>ZOL</scene></td></tr>
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{{STRUCTURE_2f8c| PDB=2f8c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8c OCA], [https://pdbe.org/2f8c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8c RCSB], [https://www.ebi.ac.uk/pdbsum/2f8c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/f8/2f8c_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2f8c ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of FPPS in complex with Zoledronate===
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==See Also==
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*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
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__TOC__
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 16892359 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16892359}}
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==About this Structure==
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2F8C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F8C OCA].
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==Reference==
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Structural basis for the exceptional in vivo efficacy of bisphosphonate drugs., Rondeau JM, Bitsch F, Bourgier E, Geiser M, Hemmig R, Kroemer M, Lehmann S, Ramage P, Rieffel S, Strauss A, Green JR, Jahnke W, ChemMedChem. 2006 Feb;1(2):267-73. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16892359 16892359]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bitsch, F.]]
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[[Category: Bitsch F]]
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[[Category: Bourgier, E.]]
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[[Category: Bourgier E]]
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[[Category: Geiser, M.]]
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[[Category: Geiser M]]
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[[Category: Green, J R.]]
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[[Category: Green JR]]
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[[Category: Hemmig, R.]]
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[[Category: Hemmig R]]
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[[Category: Jahnke, W.]]
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[[Category: Jahnke W]]
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[[Category: Kroemer, M.]]
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[[Category: Kroemer M]]
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[[Category: Lehmann, S.]]
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[[Category: Lehmann S]]
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[[Category: Ramage, P.]]
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[[Category: Ramage P]]
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[[Category: Rieffel, S.]]
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[[Category: Rieffel S]]
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[[Category: Rondeau, J M.]]
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[[Category: Rondeau J-M]]
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[[Category: Strauss, A.]]
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[[Category: Strauss A]]
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[[Category: Bisphosphonate inhibitor]]
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[[Category: Cholesterol biosynthesis]]
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[[Category: Isoprene biosynthesis]]
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[[Category: Mevalonate pathway]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:57:14 2008''
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Current revision

Crystal structure of FPPS in complex with Zoledronate

PDB ID 2f8c

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