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2fbn

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{{Seed}}
 
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[[Image:2fbn.png|left|200px]]
 
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<!--
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==Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain==
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The line below this paragraph, containing "STRUCTURE_2fbn", creates the "Structure Box" on the page.
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<StructureSection load='2fbn' size='340' side='right'caption='[[2fbn]], [[Resolution|resolution]] 1.63&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2fbn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2FBN FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2fbn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2fbn OCA], [https://pdbe.org/2fbn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2fbn RCSB], [https://www.ebi.ac.uk/pdbsum/2fbn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2fbn ProSAT]</span></td></tr>
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{{STRUCTURE_2fbn| PDB=2fbn | SCENE= }}
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</table>
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== Function ==
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===Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain===
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[https://www.uniprot.org/uniprot/FKB35_PLAF7 FKB35_PLAF7] Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).<ref>PMID:15664653</ref> <ref>PMID:15850699</ref> <ref>PMID:17289400</ref> <ref>PMID:23974147</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17125854}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17125854 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/fb/2fbn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17125854}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2fbn ConSurf].
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2FBN is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FBN OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:17125854</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Plasmodium falciparum]]
[[Category: Plasmodium falciparum]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bochkarev, A.]]
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[[Category: Bochkarev A]]
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[[Category: Dong, A.]]
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[[Category: Dong A]]
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[[Category: Edwards, A M.]]
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[[Category: Edwards AM]]
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[[Category: Hills, T.]]
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[[Category: Hills T]]
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[[Category: Hui, R.]]
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[[Category: Hui R]]
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[[Category: Koeieradzki, I.]]
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[[Category: Koeieradzki I]]
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[[Category: Lew, J.]]
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[[Category: Lew J]]
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[[Category: Melone, M.]]
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[[Category: Melone M]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundararajan E]]
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[[Category: Sundararajan, E.]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M.]]
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[[Category: Wasney G]]
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[[Category: Wasney, G.]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J.]]
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[[Category: Zhao Y]]
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[[Category: Zhao, Y.]]
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[[Category: Pfl2275c]]
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[[Category: Sgc]]
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[[Category: Structural genomic]]
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[[Category: Structural genomics consortium]]
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[[Category: Sulfur sad]]
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[[Category: Tpr-containing domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 17:32:00 2009''
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Current revision

Plasmodium falciparum putative FK506-binding protein PFL2275c, C-terminal TPR-containing domain

PDB ID 2fbn

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