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2g49

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[[Image:2g49.png|left|200px]]
 
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==Crystal structure of human insulin-degrading enzyme in complex with glucagon==
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The line below this paragraph, containing "STRUCTURE_2g49", creates the "Structure Box" on the page.
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<StructureSection load='2g49' size='340' side='right'caption='[[2g49]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2g49]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G49 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G49 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene></td></tr>
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{{STRUCTURE_2g49| PDB=2g49 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g49 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g49 OCA], [https://pdbe.org/2g49 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g49 RCSB], [https://www.ebi.ac.uk/pdbsum/2g49 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g49 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of human insulin-degrading enzyme in complex with glucagon===
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== Function ==
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[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 17051221 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/2g49_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_17051221}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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[[2g49]] is a 4 chain structure of [[Glucagon]] and [[Insulin-Degrading Enzyme]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G49 OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g49 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
*[[Glucagon|Glucagon]]
*[[Glucagon|Glucagon]]
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]]
*[[Insulin-Degrading Enzyme|Insulin-Degrading Enzyme]]
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*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
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==Reference==
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== References ==
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<ref group="xtra">PMID:017051221</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Insulysin]]
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[[Category: Large Structures]]
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[[Category: Shen, Y.]]
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[[Category: Shen Y]]
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[[Category: Tang, W J.]]
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[[Category: Tang W-J]]
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[[Category: Hydrolase]]
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[[Category: Protein-peptide complex]]
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Current revision

Crystal structure of human insulin-degrading enzyme in complex with glucagon

PDB ID 2g49

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OCA

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