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2g4r

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[[Image:2g4r.jpg|left|200px]]
 
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{{Structure
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==anomalous substructure of MogA==
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|PDB= 2g4r |SIZE=350|CAPTION= <scene name='initialview01'>2g4r</scene>, resolution 1.92&Aring;
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<StructureSection load='2g4r' size='340' side='right'caption='[[2g4r]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>
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<table><tr><td colspan='2'>[[2g4r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G4R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2G4R FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
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|GENE= mog ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2g4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g4r OCA], [https://pdbe.org/2g4r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2g4r RCSB], [https://www.ebi.ac.uk/pdbsum/2g4r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2g4r ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2g4h|2G4H]], [[2g4i|2G4I]], [[2g4j|2G4J]], [[2g4k|2G4K]], [[2g4l|2G4L]], [[2g4m|2G4M]], [[2g4n|2G4N]], [[2g4o|2G4O]], [[2g4p|2G4P]], [[2g4q|2G4Q]], [[2g4s|2G4S]], [[2g4t|2G4T]], [[2g4u|2G4U]], [[2g4v|2G4V]], [[2g4w|2G4W]], [[2g4x|2G4X]], [[2g4y|2G4Y]], [[2g4z|2G4Z]], [[2g51|2G51]], [[2g52|2G52]], [[2g55|2G55]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2g4r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2g4r OCA], [http://www.ebi.ac.uk/pdbsum/2g4r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2g4r RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/O53877_MYCTO O53877_MYCTO]
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== Evolutionary Conservation ==
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'''anomalous substructure of MogA'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/g4/2g4r_consurf.spt"</scriptWhenChecked>
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23 different crystal forms of 19 different biological macromolecules were examined with respect to their anomalously scattering substructures using diffraction data collected at a wavelength of 2.0 A (6.2 keV). In more than 90% of the cases the substructure was found to contain more than just the protein S atoms. The data presented suggest that chloride, sulfate, phosphate or metal ions from the buffer or even from the purification protocol are frequently bound to the protein molecule and that these ions are often overlooked, especially if they are not bound at full occupancy. Thus, in order to fully describe the macromolecule under study, it seems desirable that any structure determination be complemented with a long-wavelength data set.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2G4R is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G4R OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2g4r ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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On the routine use of soft X-rays in macromolecular crystallography. Part IV. Efficient determination of anomalous substructures in biomacromolecules using longer X-ray wavelengths., Mueller-Dieckmann C, Panjikar S, Schmidt A, Mueller S, Kuper J, Geerlof A, Wilmanns M, Singh RK, Tucker PA, Weiss MS, Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):366-80. Epub 2007, Feb 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17327674 17327674]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Single protein]]
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[[Category: Mueller-Dieckmann C]]
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[[Category: Mueller-Dieckmann, C.]]
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[[Category: Weiss MS]]
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[[Category: Weiss, M S.]]
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[[Category: anomalous substructure of moga]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:11:48 2008''
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Current revision

anomalous substructure of MogA

PDB ID 2g4r

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