2gjs
From Proteopedia
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==The crystal structure of human RRAD in complex with GDP== | ==The crystal structure of human RRAD in complex with GDP== | ||
| - | <StructureSection load='2gjs' size='340' side='right' caption='[[2gjs]], [[Resolution|resolution]] 1.90Å' scene=''> | + | <StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref> |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjs_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjs_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjs ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[GTP-binding protein|GTP-binding protein]] | + | *[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Berridge | + | [[Category: Arrowsmith C]] |
| - | [[Category: Bray | + | [[Category: Berridge G]] |
| - | [[Category: Burgess | + | [[Category: Bray J]] |
| - | [[Category: Debreczeni | + | [[Category: Burgess N]] |
| - | + | [[Category: Debreczeni J]] | |
| - | [[Category: Doyle | + | [[Category: Doyle D]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins JM]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Pantic | + | [[Category: Pantic N]] |
| - | + | [[Category: Schoch G]] | |
| - | [[Category: Schoch | + | [[Category: Smee CEA]] |
| - | [[Category: Smee | + | [[Category: Soundararajan M]] |
| - | [[Category: Soundararajan | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Turnbull AP]] |
| - | [[Category: Turnbull | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Yang X]] |
| - | [[Category: Yang | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
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Current revision
The crystal structure of human RRAD in complex with GDP
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Berridge G | Bray J | Burgess N | Debreczeni J | Doyle D | Edwards A | Elkins JM | Gileadi C | Pantic N | Schoch G | Smee CEA | Soundararajan M | Sundstrom M | Turnbull AP | Weigelt J | Yang X | Von Delft F
