2gjs

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:28, 14 February 2024) (edit) (undo)
 
(12 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gjs.gif|left|200px]]
 
-
{{Structure
+
==The crystal structure of human RRAD in complex with GDP==
-
|PDB= 2gjs |SIZE=350|CAPTION= <scene name='initialview01'>2gjs</scene>, resolution 1.90&Aring;
+
<StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene> and <scene name='pdbligand=GDP:GUANOSINE-5&#39;-DIPHOSPHATE'>GDP</scene>
+
<table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
|GENE= RRAD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjs_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjs ConSurf].
 +
<div style="clear:both"></div>
-
'''The crystal structure of human RRAD in complex with GDP'''
+
==See Also==
-
 
+
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
-
 
+
== References ==
-
==Disease==
+
<references/>
-
Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179617 179617]]
+
__TOC__
-
 
+
</StructureSection>
-
==About this Structure==
+
-
2GJS is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA].
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Single protein]]
+
[[Category: Large Structures]]
-
[[Category: Arrowsmith, C.]]
+
[[Category: Arrowsmith C]]
-
[[Category: Berridge, G.]]
+
[[Category: Berridge G]]
-
[[Category: Bray, J.]]
+
[[Category: Bray J]]
-
[[Category: Burgess, N.]]
+
[[Category: Burgess N]]
-
[[Category: Debreczeni, J.]]
+
[[Category: Debreczeni J]]
-
[[Category: Delft, F von.]]
+
[[Category: Doyle D]]
-
[[Category: Doyle, D.]]
+
[[Category: Edwards A]]
-
[[Category: Edwards, A.]]
+
[[Category: Elkins JM]]
-
[[Category: Elkins, J M.]]
+
[[Category: Gileadi C]]
-
[[Category: Gileadi, C.]]
+
[[Category: Pantic N]]
-
[[Category: Pantic, N.]]
+
[[Category: Schoch G]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Smee CEA]]
-
[[Category: Schoch, G.]]
+
[[Category: Soundararajan M]]
-
[[Category: Smee, C E.A.]]
+
[[Category: Sundstrom M]]
-
[[Category: Soundararajan, M.]]
+
[[Category: Turnbull AP]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Weigelt J]]
-
[[Category: Turnbull, A P.]]
+
[[Category: Yang X]]
-
[[Category: Weigelt, J.]]
+
[[Category: Von Delft F]]
-
[[Category: Yang, X.]]
+
-
[[Category: GDP]]
+
-
[[Category: MG]]
+
-
[[Category: gdp/gtp binding]]
+
-
[[Category: gtp hydrolysis]]
+
-
[[Category: rrad]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:11:00 2008''
+

Current revision

The crystal structure of human RRAD in complex with GDP

PDB ID 2gjs

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gjs"
Personal tools