2gjs

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(New page: 200px<br /> <applet load="2gjs" size="450" color="white" frame="true" align="right" spinBox="true" caption="2gjs, resolution 1.90&Aring;" /> '''The crystal structu...)
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[[Image:2gjs.gif|left|200px]]<br />
 
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<applet load="2gjs" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2gjs, resolution 1.90&Aring;" />
 
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'''The crystal structure of human RRAD in complex with GDP'''<br />
 
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==Disease==
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==The crystal structure of human RRAD in complex with GDP==
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Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=179617 179617]]
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<StructureSection load='2gjs' size='340' side='right'caption='[[2gjs]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2gjs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GJS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gjs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gjs OCA], [https://pdbe.org/2gjs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gjs RCSB], [https://www.ebi.ac.uk/pdbsum/2gjs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gjs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RAD_HUMAN RAD_HUMAN] May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha-1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D.<ref>PMID:18056528</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gj/2gjs_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gjs ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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2GJS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MG and GDP as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2GJS OCA].
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*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C.]]
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[[Category: Arrowsmith C]]
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[[Category: Berridge, G.]]
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[[Category: Berridge G]]
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[[Category: Bray, J.]]
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[[Category: Bray J]]
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[[Category: Burgess, N.]]
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[[Category: Burgess N]]
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[[Category: Debreczeni, J.]]
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[[Category: Debreczeni J]]
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[[Category: Delft, F.von.]]
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[[Category: Doyle D]]
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[[Category: Doyle, D.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins JM]]
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[[Category: Elkins, J.M.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Pantic N]]
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[[Category: Pantic, N.]]
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[[Category: Schoch G]]
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[[Category: SGC, Structural.Genomics.Consortium.]]
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[[Category: Smee CEA]]
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[[Category: Schoch, G.]]
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[[Category: Soundararajan M]]
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[[Category: Smee, C.E.A.]]
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[[Category: Sundstrom M]]
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[[Category: Soundararajan, M.]]
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[[Category: Turnbull AP]]
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[[Category: Sundstrom, M.]]
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[[Category: Weigelt J]]
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[[Category: Turnbull, A.P.]]
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[[Category: Yang X]]
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[[Category: Weigelt, J.]]
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[[Category: Von Delft F]]
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[[Category: Yang, X.]]
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[[Category: GDP]]
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[[Category: MG]]
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[[Category: gdp/gtp binding]]
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[[Category: gtp hydrolysis]]
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[[Category: rrad]]
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[[Category: sgc]]
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[[Category: structural genomics]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:19:24 2007''
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Current revision

The crystal structure of human RRAD in complex with GDP

PDB ID 2gjs

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