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2gom

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[[Image:2gom.jpg|left|200px]]
 
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==Crystal structure of Efb-C from Staphylococcus aureus==
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The line below this paragraph, containing "STRUCTURE_2gom", creates the "Structure Box" on the page.
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<StructureSection load='2gom' size='340' side='right'caption='[[2gom]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gom]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus_subsp._aureus_Mu50 Staphylococcus aureus subsp. aureus Mu50]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GOM FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gom FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gom OCA], [https://pdbe.org/2gom PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gom RCSB], [https://www.ebi.ac.uk/pdbsum/2gom PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gom ProSAT]</span></td></tr>
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{{STRUCTURE_2gom| PDB=2gom | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIB_STAAM FIB_STAAM] Binds to host fibrinogen (By similarity).
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'''Crystal structure of Efb-C from Staphylococcus aureus'''
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==See Also==
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*[[Fibrinogen binding protein|Fibrinogen binding protein]]
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__TOC__
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==Overview==
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</StructureSection>
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To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
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[[Category: Large Structures]]
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[[Category: Staphylococcus aureus subsp. aureus Mu50]]
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==About this Structure==
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[[Category: Geisbrecht BV]]
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2GOM is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GOM OCA].
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[[Category: Hammel M]]
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==Reference==
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A structural basis for complement inhibition by Staphylococcus aureus., Hammel M, Sfyroera G, Ricklin D, Magotti P, Lambris JD, Geisbrecht BV, Nat Immunol. 2007 Apr;8(4):430-7. Epub 2007 Mar 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17351618 17351618]
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[[Category: Single protein]]
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[[Category: Staphylococcus aureus]]
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[[Category: Geisbrecht, B V.]]
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[[Category: Hammel, M.]]
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[[Category: Three-helix closed bundle with left-hand twist]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:20:33 2008''
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Current revision

Crystal structure of Efb-C from Staphylococcus aureus

PDB ID 2gom

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