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2gsr

From Proteopedia

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[[Image:2gsr.png|left|200px]]
 
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==Structure of porcine class pi glutathione s-transferase==
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The line below this paragraph, containing "STRUCTURE_2gsr", creates the "Structure Box" on the page.
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<StructureSection load='2gsr' size='340' side='right'caption='[[2gsr]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2gsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gsr 1gsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSR FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr>
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{{STRUCTURE_2gsr| PDB=2gsr | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsr OCA], [https://pdbe.org/2gsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsr RCSB], [https://www.ebi.ac.uk/pdbsum/2gsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsr ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GSTP1_PIG GSTP1_PIG] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity).
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsr_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsr ConSurf].
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<div style="clear:both"></div>
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===Structure of porcine class pi glutathione s-transferase===
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==See Also==
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*[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_7932743}}, adds the Publication Abstract to the page
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 7932743 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7932743}}
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==About this Structure==
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[[2gsr]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gsr 1gsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSR OCA].
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==Reference==
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<ref group="xtra">PMID:007932743</ref><references group="xtra"/>
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[[Category: Glutathione transferase]]
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[[Category: Sus scrofa]]
[[Category: Sus scrofa]]
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[[Category: Dirr, H W.]]
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[[Category: Dirr HW]]
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[[Category: Huber, R.]]
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[[Category: Huber R]]
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[[Category: Reinemer, P.]]
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[[Category: Reinemer P]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure of porcine class pi glutathione s-transferase

PDB ID 2gsr

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OCA

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