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2gsr
From Proteopedia
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| - | {{STRUCTURE_2gsr| PDB=2gsr | SCENE= }} | ||
| - | ===Structure of porcine class pi glutathione s-transferase=== | ||
| - | {{ABSTRACT_PUBMED_7932743}} | ||
| - | == | + | ==Structure of porcine class pi glutathione s-transferase== |
| - | [[2gsr]] is a 2 chain structure with sequence from [ | + | <StructureSection load='2gsr' size='340' side='right'caption='[[2gsr]], [[Resolution|resolution]] 2.11Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2gsr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1gsr 1gsr]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GSR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTS:GLUTATHIONE+SULFONIC+ACID'>GTS</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gsr OCA], [https://pdbe.org/2gsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gsr RCSB], [https://www.ebi.ac.uk/pdbsum/2gsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gsr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GSTP1_PIG GSTP1_PIG] Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gs/2gsr_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2gsr ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Glutathione S-transferase|Glutathione S-transferase]] | + | *[[Glutathione S-transferase 3D structures|Glutathione S-transferase 3D structures]] |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| - | [[Category: | + | |
[[Category: Sus scrofa]] | [[Category: Sus scrofa]] | ||
| - | [[Category: Dirr | + | [[Category: Dirr HW]] |
| - | [[Category: Huber | + | [[Category: Huber R]] |
| - | [[Category: Reinemer | + | [[Category: Reinemer P]] |
| - | + | ||
Current revision
Structure of porcine class pi glutathione s-transferase
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