2h0n

{{Structure

|PDB= 2h0n |SIZE=350|CAPTION= <scene name='initialview01'>2h0n</scene>, resolution 1.53&Aring;

|SITE= <scene name='pdbsite=AC1:2hp+Binding+Site+For+Residue+A+9'>AC1</scene> and <scene name='pdbsite=AC2:2hp+Binding+Site+For+Residue+B+9'>AC2</scene>

|LIGAND= <scene name='pdbligand=2HP:DIHYDROGENPHOSPHATE+ION'>2HP</scene>, <scene name='pdbligand=XAL:[(1S,4R,6R)-6-HYDROXY-4-(ADENIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XAL</scene>, <scene name='pdbligand=XCL:[(1S,4R,6R)-6-HYDROXY-4-(CYTOSIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XCL</scene>, <scene name='pdbligand=XGL:[(1S,4R,6R)-6-HYDROXY-4-(GUANIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XGL</scene>, <scene name='pdbligand=XTL:[(1S,4R,6R)-6-HYDROXY-4-(THYMIN-9-YL)CYCLOHEX-2-EN-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>XTL</scene>

|ACTIVITY=

|GENE=

|DOMAIN=

|RELATEDENTRY=

|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h0n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0n OCA], [http://www.ebi.ac.uk/pdbsum/2h0n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h0n RCSB]</span>

}}

'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''

 

 

==Overview==

CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.

 

==About this Structure==

2H0N is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H0N OCA].

 

==Reference==

Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC., Robeyns K, Herdewijn P, Van Meervelt L, J Am Chem Soc. 2008 Feb 13;130(6):1979-84. Epub 2008 Jan 17. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18198873 18198873]

[[Category: Protein complex]]

[[Category: Meervelt, L Van.]]

[[Category: Robeyns, K.]]

[[Category: cyclohexene nucleic acid]]

[[Category: dna analogue]]

[[Category: double helix]]

[[Category: left-handed]]