2h1c

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{{Seed}}
 
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[[Image:2h1c.png|left|200px]]
 
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==Crystal Structure of FitAcB from Neisseria gonorrhoeae==
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The line below this paragraph, containing "STRUCTURE_2h1c", creates the "Structure Box" on the page.
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<StructureSection load='2h1c' size='340' side='right'caption='[[2h1c]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2h1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2H1C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_2h1c| PDB=2h1c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2h1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h1c OCA], [https://pdbe.org/2h1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2h1c RCSB], [https://www.ebi.ac.uk/pdbsum/2h1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2h1c ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of FitAcB from Neisseria gonorrhoeae===
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== Function ==
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[https://www.uniprot.org/uniprot/FITB_NEIG1 FITB_NEIG1] Toxic component of a toxin-antitoxin (TA) module. Plays a role in the speed with which bacteria traverse human epithelial cells; disruption of the locus increases the speed of trafficking about 2-4-fold. FitAB binds to its own promoter better than FitA alone. The expected nuclease activity was not observed for the FitAB complex, perhaps because FitA (the antitoxin) prevents metal binding and thus catalysis by FitB.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_16982615}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 16982615 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h1/2h1c_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_16982615}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2H1C is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Neisseria_gonorrhoeae Neisseria gonorrhoeae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2H1C OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2h1c ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs., Mattison K, Wilbur JS, So M, Brennan RG, J Biol Chem. 2006 Dec 8;281(49):37942-51. Epub 2006 Sep 18. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16982615 16982615]
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Neisseria gonorrhoeae]]
[[Category: Neisseria gonorrhoeae]]
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[[Category: Protein complex]]
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[[Category: Brennan RG]]
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[[Category: Brennan, R G.]]
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[[Category: Mattison K]]
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[[Category: Mattison, K.]]
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[[Category: So M]]
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[[Category: So, M.]]
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[[Category: Wilbur JS]]
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[[Category: Wilbur, J S.]]
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[[Category: Dna binding]]
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[[Category: Gene regulation]]
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[[Category: Pin domain]]
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[[Category: Rhh domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:46:11 2008''
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Current revision

Crystal Structure of FitAcB from Neisseria gonorrhoeae

PDB ID 2h1c

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