This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2hpo

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:33, 14 February 2024) (edit) (undo)
 
(10 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:2hpo.png|left|200px]]
 
-
<!--
+
==Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site==
-
The line below this paragraph, containing "STRUCTURE_2hpo", creates the "Structure Box" on the page.
+
<StructureSection load='2hpo' size='340' side='right'caption='[[2hpo]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2hpo]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HPO FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-
{{STRUCTURE_2hpo| PDB=2hpo | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hpo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hpo OCA], [https://pdbe.org/2hpo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hpo RCSB], [https://www.ebi.ac.uk/pdbsum/2hpo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hpo ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AMPN_ECOLI AMPN_ECOLI] Aminopeptidase N is involved in the degradation of intracellular peptides generated by protein breakdown during normal growth as well as in response to nutrient starvation.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hp/2hpo_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2hpo ConSurf].
 +
<div style="clear:both"></div>
-
===Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site===
+
==See Also==
-
 
+
*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_16938892}}, adds the Publication Abstract to the page
+
[[Category: Escherichia coli K-12]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 16938892 is the PubMed ID number.
+
[[Category: Large Structures]]
-
-->
+
[[Category: Addlagatta A]]
-
{{ABSTRACT_PUBMED_16938892}}
+
[[Category: Gay L]]
-
 
+
[[Category: Matthews BW]]
-
==About this Structure==
+
-
2HPO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HPO OCA].
+
-
 
+
-
==Reference==
+
-
Structure of aminopeptidase N from Escherichia coli suggests a compartmentalized, gated active site., Addlagatta A, Gay L, Matthews BW, Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13339-44. Epub 2006 Aug 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16938892 16938892]
+
-
[[Category: Escherichia coli]]
+
-
[[Category: Membrane alanyl aminopeptidase]]
+
-
[[Category: Single protein]]
+
-
[[Category: Addlagatta, A.]]
+
-
[[Category: Gay, L.]]
+
-
[[Category: Matthews, B W.]]
+
-
[[Category: Closed]]
+
-
[[Category: Compartmentalized active site]]
+
-
[[Category: Multidomain]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 22:48:32 2008''
+

Current revision

Structure of Aminopeptidase N from E. coli Suggests a Compartmentalized, Gated Active Site

PDB ID 2hpo

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hpo"
Personal tools