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3msv
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3msv is ON HOLD until sometime in the future Authors: Yeh, T.L., Amzel, L.M., Bianchet, M.A. Description: The hypoxic regulator of sterol synthesis...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor== | |
| - | + | <StructureSection load='3msv' size='340' side='right'caption='[[3msv]], [[Resolution|resolution]] 2.18Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3msv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MSV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MSV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.18Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3msv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3msv OCA], [https://pdbe.org/3msv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3msv RCSB], [https://www.ebi.ac.uk/pdbsum/3msv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3msv ProSAT]</span></td></tr> | |
| - | '' | + | </table> |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ETT1_SCHPO ETT1_SCHPO] Required for correct translation termination (By similarity). Positive regulator of the stability of the N-terminal transcription factor domain (Sre1N) of sre1 which is released from the membrane and enters the nucleus to activate hypoxic gene expression. Acts also as a direct inhibitor of ofd1. Functions probably by inhibiting the ability of the ofd1 to accelerate Sre1N degradation in absence of oxygen.<ref>PMID:15116432</ref> <ref>PMID:19158663</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Schizosaccharomyces pombe]] | ||
| + | [[Category: Amzel LM]] | ||
| + | [[Category: Bianchet MA]] | ||
| + | [[Category: Yeh TL]] | ||
Current revision
The hypoxic regulator of sterol synthesis Nro1 is a nuclear import adaptor
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