This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3nfr
From Proteopedia
(Difference between revisions)
| (3 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Casimiroin analog inhibitor of quinone reductase 2== | ==Casimiroin analog inhibitor of quinone reductase 2== | ||
| - | <StructureSection load='3nfr' size='340' side='right' caption='[[3nfr]], [[Resolution|resolution]] 1.57Å' scene=''> | + | <StructureSection load='3nfr' size='340' side='right'caption='[[3nfr]], [[Resolution|resolution]] 1.57Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3nfr]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[3nfr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NFR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NFR FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.57Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EWQ:6,8-DIMETHOXY-1,4-DIMETHYLQUINOLIN-2(1H)-ONE'>EWQ</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id=' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nfr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nfr OCA], [https://pdbe.org/3nfr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nfr RCSB], [https://www.ebi.ac.uk/pdbsum/3nfr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nfr ProSAT]</span></td></tr> |
| - | < | + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref> | ||
==See Also== | ==See Also== | ||
| - | *[[Quinone reductase|Quinone reductase]] | + | *[[Quinone reductase 3D structures|Quinone reductase 3D structures]] |
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Cushman | + | [[Category: Large Structures]] |
| - | [[Category: Jermihov | + | [[Category: Cushman M]] |
| - | [[Category: Maiti | + | [[Category: Jermihov K]] |
| - | [[Category: Mesecar | + | [[Category: Maiti A]] |
| - | [[Category: Sturdy | + | [[Category: Mesecar AD]] |
| - | + | [[Category: Sturdy M]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Casimiroin analog inhibitor of quinone reductase 2
| |||||||||||
