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3nlg

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[[Image:3nlg.png|left|200px]]
 
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{{STRUCTURE_3nlg| PDB=3nlg | SCENE= }}
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==Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine==
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<StructureSection load='3nlg' size='340' side='right'caption='[[3nlg]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
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===Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'R)-3'-[2"-(3'''-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3nlg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NLG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NLG FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20958055}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.38&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CAD:CACODYLIC+ACID'>CAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=H4B:5,6,7,8-TETRAHYDROBIOPTERIN'>H4B</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JSR:6-{[(3R,4S)-4-(2-{[2-(3-FLUOROPHENYL)ETHYL]AMINO}ETHOXY)PYRROLIDIN-3-YL]METHYL}-4-METHYLPYRIDIN-2-AMINE'>JSR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nlg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nlg OCA], [https://pdbe.org/3nlg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nlg RCSB], [https://www.ebi.ac.uk/pdbsum/3nlg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nlg ProSAT]</span></td></tr>
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[[3nlg]] is a 2 chain structure of [[Nitric Oxide Synthase]] with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NLG OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NOS3_BOVIN NOS3_BOVIN] Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
==See Also==
==See Also==
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*[[Nitric Oxide Synthase|Nitric Oxide Synthase]]
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*[[Nitric Oxide Synthase 3D structures|Nitric Oxide Synthase 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:020958055</ref><references group="xtra"/>
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[[Category: Bos taurus]]
[[Category: Bos taurus]]
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[[Category: Nitric-oxide synthase]]
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[[Category: Large Structures]]
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[[Category: Delker, S L.]]
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[[Category: Delker SL]]
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[[Category: Ji, H.]]
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[[Category: Ji H]]
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[[Category: Li, H.]]
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[[Category: Li H]]
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[[Category: Martasek, P.]]
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[[Category: Martasek P]]
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[[Category: Poulos, T L.]]
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[[Category: Poulos TL]]
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[[Category: Roman, L.]]
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[[Category: Roman L]]
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[[Category: Silverman, R B.]]
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[[Category: Silverman RB]]
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[[Category: Heme enzyme]]
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[[Category: Nitric oxide synthase]]
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[[Category: Oxidoreductase]]
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[[Category: Substrate inhibitor]]
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Current revision

Structure of endothelial nitric oxide synthase heme domain complexed with 6-{{(3'S,4'R)-3'-[2"-(3-fluorophenethylamino)ethoxy]pyrrolidin-4'-yl}methyl}-4-methylpyridin-2-amine

PDB ID 3nlg

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