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3o21
From Proteopedia
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| - | [[Image:3o21.jpg|left|200px]] | ||
| - | < | + | ==High resolution structure of GluA3 N-terminal domain (NTD)== |
| - | + | <StructureSection load='3o21' size='340' side='right'caption='[[3o21]], [[Resolution|resolution]] 2.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3o21]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O21 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O21 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.201Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o21 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o21 OCA], [https://pdbe.org/3o21 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o21 RCSB], [https://www.ebi.ac.uk/pdbsum/3o21 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o21 ProSAT]</span></td></tr> | |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GRIA3_RAT GRIA3_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (By similarity). | ||
| - | == | + | ==See Also== |
| - | + | *[[Glutamate receptor 3D structures|Glutamate receptor 3D structures]] | |
| - | + | __TOC__ | |
| - | < | + | </StructureSection> |
| - | + | [[Category: Large Structures]] | |
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| - | [[ | + | |
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[[Category: Rattus norvegicus]] | [[Category: Rattus norvegicus]] | ||
| - | [[Category: Babu | + | [[Category: Babu MM]] |
| - | [[Category: Greger | + | [[Category: Greger IH]] |
| - | [[Category: Jensen | + | [[Category: Jensen MH]] |
| - | [[Category: Penn | + | [[Category: Penn AC]] |
| - | [[Category: Rossmann | + | [[Category: Rossmann M]] |
| - | [[Category: Sukumaran | + | [[Category: Sukumaran M]] |
| - | [[Category: Veprintsev | + | [[Category: Veprintsev DB]] |
Current revision
High resolution structure of GluA3 N-terminal domain (NTD)
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