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3o3u

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[[Image:3o3u.png|left|200px]]
 
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==Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)==
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The line below this paragraph, containing "STRUCTURE_3o3u", creates the "Structure Box" on the page.
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<StructureSection load='3o3u' size='340' side='right'caption='[[3o3u]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o3u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O3U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.497&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=PRD_900009:alpha-maltotriose'>PRD_900009</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3o3u| PDB=3o3u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o3u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o3u OCA], [https://pdbe.org/3o3u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o3u RCSB], [https://www.ebi.ac.uk/pdbsum/3o3u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o3u ProSAT]</span></td></tr>
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</table>
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===Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)===
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== Function ==
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[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/RAGE_HUMAN RAGE_HUMAN] Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space.<ref>PMID:19906677</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20943659 is the PubMed ID number.
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</StructureSection>
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[[Category: Escherichia coli]]
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{{ABSTRACT_PUBMED_20943659}}
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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==About this Structure==
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[[Category: Boyington JC]]
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[[3o3u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli,_homo_sapiens Escherichia coli, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O3U OCA].
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[[Category: Park H]]
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==Reference==
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<ref group="xtra">PMID:20943659</ref><references group="xtra"/>
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[[Category: Escherichia coli, homo sapiens]]
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[[Category: Boyington, J C.]]
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[[Category: Park, H.]]
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Current revision

Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE)

PDB ID 3o3u

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