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3o4x

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{{Seed}}
 
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[[Image:3o4x.jpg|left|200px]]
 
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==Crystal structure of complex between amino and carboxy terminal fragments of mDia1==
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The line below this paragraph, containing "STRUCTURE_3o4x", creates the "Structure Box" on the page.
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<StructureSection load='3o4x' size='340' side='right'caption='[[3o4x]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o4x]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O4X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o4x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o4x OCA], [https://pdbe.org/3o4x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o4x RCSB], [https://www.ebi.ac.uk/pdbsum/3o4x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o4x ProSAT]</span></td></tr>
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{{STRUCTURE_3o4x| PDB=3o4x | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of complex between amino and carboxy terminal fragments of mDia1===
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[https://www.uniprot.org/uniprot/DIAP1_MOUSE DIAP1_MOUSE] Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures, such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis, and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration. Has neurite outgrowth promoting activity. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity).<ref>PMID:9214622</ref> <ref>PMID:10678165</ref> <ref>PMID:15044801</ref> <ref>PMID:18572016</ref>
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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3O4X is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O4X OCA].
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Eck, M J.]]
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[[Category: Eck MJ]]
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[[Category: Nezami, A.]]
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[[Category: Nezami A]]
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[[Category: Toms, A V.]]
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[[Category: Toms AV]]
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[[Category: Actin binding]]
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[[Category: Actin nucleator]]
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[[Category: Autoinhibition]]
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[[Category: Protein binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 13 10:49:59 2010''
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Current revision

Crystal structure of complex between amino and carboxy terminal fragments of mDia1

PDB ID 3o4x

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