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3o5z

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[[Image:3o5z.png|left|200px]]
 
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==Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)==
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The line below this paragraph, containing "STRUCTURE_3o5z", creates the "Structure Box" on the page.
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<StructureSection load='3o5z' size='340' side='right'caption='[[3o5z]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o5z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O5Z FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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{{STRUCTURE_3o5z| PDB=3o5z | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o5z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o5z OCA], [https://pdbe.org/3o5z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o5z RCSB], [https://www.ebi.ac.uk/pdbsum/3o5z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o5z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/P85B_HUMAN P85B_HUMAN] Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.
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===Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)===
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==See Also==
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*[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3o5z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O5Z OCA].
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Chen, S.]]
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[[Category: Large Structures]]
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[[Category: Hilgenfeld, R.]]
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[[Category: Chen S]]
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[[Category: Lei, J.]]
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[[Category: Hilgenfeld R]]
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[[Category: Ponnusamy, R.]]
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[[Category: Lei J]]
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[[Category: Tan, J.]]
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[[Category: Ponnusamy R]]
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[[Category: Xiao, Y.]]
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[[Category: Tan J]]
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[[Category: Protein binding]]
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[[Category: Xiao Y]]
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[[Category: Src homology 3 domain]]
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Current revision

Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K)

PDB ID 3o5z

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