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3o9j

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{{Seed}}
 
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[[Image:3o9j.jpg|left|200px]]
 
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==Influenza NA in complex with compound 5==
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The line below this paragraph, containing "STRUCTURE_3o9j", creates the "Structure Box" on the page.
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<StructureSection load='3o9j' size='340' side='right'caption='[[3o9j]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o9j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/duck/Ukraine/1/1963(H3N8)) Influenza A virus (A/duck/Ukraine/1/1963(H3N8))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.0002&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=RP6:5-(ACETYLAMINO)-2,6-ANHYDRO-3,5-DIDEOXY-3-PROP-2-EN-1-YL-D-GLYCERO-D-GALACTO-NON-2-ENONIC+ACID'>RP6</scene></td></tr>
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{{STRUCTURE_3o9j| PDB=3o9j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9j OCA], [https://pdbe.org/3o9j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9j RCSB], [https://www.ebi.ac.uk/pdbsum/3o9j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/NRAM_I63A3 NRAM_I63A3] Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
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===Influenza NA in complex with compound 5===
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==See Also==
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*[[Neuraminidase 3D structures|Neuraminidase 3D structures]]
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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(as it appears on PubMed at http://www.pubmed.gov), where 21081911 is the PubMed ID number.
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[[Category: Kerry PS]]
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[[Category: Russell RJ]]
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{{ABSTRACT_PUBMED_21081911}}
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==About this Structure==
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3O9J is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Viruses Viruses]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9J OCA].
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==Reference==
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<ref group="xtra">PMID:21081911</ref><references group="xtra"/>
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[[Category: Exo-alpha-sialidase]]
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[[Category: Viruses]]
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[[Category: Kerry, P S.]]
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[[Category: Russell, R J.]]
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[[Category: Hydrolase]]
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[[Category: Neuraminidase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Dec 15 08:42:55 2010''
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Current revision

Influenza NA in complex with compound 5

PDB ID 3o9j

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