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3o9o

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==Crystal Structure of GBS1074, an Esat-6 homologue from Group B Streptococcus==
==Crystal Structure of GBS1074, an Esat-6 homologue from Group B Streptococcus==
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<StructureSection load='3o9o' size='340' side='right' caption='[[3o9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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<StructureSection load='3o9o' size='340' side='right'caption='[[3o9o]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3o9o]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Stra3 Stra3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3O9O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3o9o]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_agalactiae_NEM316 Streptococcus agalactiae NEM316]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O9O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O9O FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">gbs1074 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=211110 STRA3])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3o9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9o OCA], [http://pdbe.org/3o9o PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3o9o RCSB], [http://www.ebi.ac.uk/pdbsum/3o9o PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9o ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o9o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o9o OCA], [https://pdbe.org/3o9o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o9o RCSB], [https://www.ebi.ac.uk/pdbsum/3o9o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o9o ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8E5F8_STRA3 Q8E5F8_STRA3]
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ESAT-6 is a well characterized secreted protein from Mycobacterium tuberculosis and represents the archetype of the WXG100 family of proteins. Genes encoding ESAT-6 homologues have been identified in the genome of the human pathogen Streptococcus agalactiae; one of these genes, esxA, has been cloned and the recombinant protein has been crystallized. In contrast to M. tuberculosis ESAT-6, the crystal structure of GBS1074 reveals a homodimeric structure similar to homologous structures from Staphylococcus aureus and Helicobacter pylori. Intriguingly, GBS1074 forms elongated fibre-like assemblies in the crystal structure.
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The homodimeric GBS1074 from Streptococcus agalactiae.,Shukla A, Pallen M, Anthony M, White SA Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 1;66(Pt, 11):1421-5. Epub 2010 Oct 27. PMID:21045286<ref>PMID:21045286</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3o9o" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Stra3]]
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[[Category: Large Structures]]
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[[Category: Anthony, M]]
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[[Category: Streptococcus agalactiae NEM316]]
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[[Category: Shukla, A]]
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[[Category: Anthony M]]
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[[Category: White, S A]]
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[[Category: Shukla A]]
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[[Category: 4-helix bundle]]
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[[Category: White SA]]
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[[Category: Putative secreted protein]]
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[[Category: Putative virulence factor]]
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[[Category: Unknown function]]
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[[Category: Wxg100]]
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Current revision

Crystal Structure of GBS1074, an Esat-6 homologue from Group B Streptococcus

PDB ID 3o9o

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