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2i0o

From Proteopedia

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[[Image:2i0o.gif|left|200px]]
 
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{{Structure
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==Crystal structure of Anopheles gambiae Ser/Thr phosphatase complexed with Zn2+==
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|PDB= 2i0o |SIZE=350|CAPTION= <scene name='initialview01'>2i0o</scene>, resolution 1.70&Aring;
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<StructureSection load='2i0o' size='340' side='right'caption='[[2i0o]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+A+579'>AC1</scene>, <scene name='pdbsite=AC2:Zn+Binding+Site+For+Residue+A+580'>AC2</scene>, <scene name='pdbsite=AC3:Zn+Binding+Site+For+Residue+A+581'>AC3</scene>, <scene name='pdbsite=AC4:Zn+Binding+Site+For+Residue+A+582'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+A+583'>AC5</scene> and <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+584'>AC6</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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<table><tr><td colspan='2'>[[2i0o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I0O FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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|DOMAIN=<span class='plainlinks'>[http://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00143 PP2Cc]</span>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0o OCA], [https://pdbe.org/2i0o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i0o RCSB], [https://www.ebi.ac.uk/pdbsum/2i0o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i0o ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/2i0o TOPSAN]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i0o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i0o OCA], [http://www.ebi.ac.uk/pdbsum/2i0o PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i0o RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/Q7PP01_ANOGA Q7PP01_ANOGA]
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== Evolutionary Conservation ==
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'''Crystal structure of Anopheles gambiae Ser/Thr phosphatase complexed with Zn2+'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==Overview==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i0/2i0o_consurf.spt"</scriptWhenChecked>
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The New York SGX Research Center for Structural Genomics (NYSGXRC) of the NIGMS Protein Structure Initiative (PSI) has applied its high-throughput X-ray crystallographic structure determination platform to systematic studies of all human protein phosphatases and protein phosphatases from biomedically-relevant pathogens. To date, the NYSGXRC has determined structures of 21 distinct protein phosphatases: 14 from human, 2 from mouse, 2 from the pathogen Toxoplasma gondii, 1 from Trypanosoma brucei, the parasite responsible for African sleeping sickness, and 2 from the principal mosquito vector of malaria in Africa, Anopheles gambiae. These structures provide insights into both normal and pathophysiologic processes, including transcriptional regulation, regulation of major signaling pathways, neural development, and type 1 diabetes. In conjunction with the contributions of other international structural genomics consortia, these efforts promise to provide an unprecedented database and materials repository for structure-guided experimental and computational discovery of inhibitors for all classes of protein phosphatases.
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2I0O is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Anopheles_gambiae Anopheles gambiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I0O OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i0o ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural genomics of protein phosphatases., Almo SC, Bonanno JB, Sauder JM, Emtage S, Dilorenzo TP, Malashkevich V, Wasserman SR, Swaminathan S, Eswaramoorthy S, Agarwal R, Kumaran D, Madegowda M, Ragumani S, Patskovsky Y, Alvarado J, Ramagopal UA, Faber-Barata J, Chance MR, Sali A, Fiser A, Zhang ZY, Lawrence DS, Burley SK, J Struct Funct Genomics. 2007 Sep;8(2-3):121-40. Epub 2007 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18058037 18058037]
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</StructureSection>
[[Category: Anopheles gambiae]]
[[Category: Anopheles gambiae]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Burley, S K.]]
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[[Category: Burley SK]]
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[[Category: Jin, X.]]
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[[Category: Jin X]]
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[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
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[[Category: Sauder JM]]
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[[Category: Sauder, J M.]]
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[[Category: Shapiro L]]
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[[Category: Shapiro, L.]]
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[[Category: beta sandwich]]
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[[Category: hydrolase]]
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[[Category: new york structural genomix research consortium]]
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[[Category: nysgxrc]]
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[[Category: phosphatase]]
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[[Category: protein structure initiative]]
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[[Category: psi]]
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[[Category: structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:38:07 2008''
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Current revision

Crystal structure of Anopheles gambiae Ser/Thr phosphatase complexed with Zn2+

PDB ID 2i0o

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