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2i46

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{{Seed}}
 
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[[Image:2i46.png|left|200px]]
 
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==Crystal structure of human TPP1==
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The line below this paragraph, containing "STRUCTURE_2i46", creates the "Structure Box" on the page.
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<StructureSection load='2i46' size='340' side='right'caption='[[2i46]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i46]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I46 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I46 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i46 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i46 OCA], [https://pdbe.org/2i46 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i46 RCSB], [https://www.ebi.ac.uk/pdbsum/2i46 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i46 ProSAT]</span></td></tr>
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{{STRUCTURE_2i46| PDB=2i46 | SCENE= }}
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</table>
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== Function ==
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===Crystal structure of human TPP1===
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[https://www.uniprot.org/uniprot/ACD_HUMAN ACD_HUMAN] Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis.<ref>PMID:15181449</ref> <ref>PMID:16166375</ref> <ref>PMID:16880378</ref> <ref>PMID:20231318</ref> <ref>PMID:17237768</ref>
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== References ==
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<references/>
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</StructureSection>
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(as it appears on PubMed at http://www.pubmed.gov), where 17237768 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17237768}}
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==About this Structure==
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2I46 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I46 OCA].
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==Reference==
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The POT1-TPP1 telomere complex is a telomerase processivity factor., Wang F, Podell ER, Zaug AJ, Yang Y, Baciu P, Cech TR, Lei M, Nature. 2007 Feb 1;445(7127):506-10. Epub 2007 Jan 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17237768 17237768]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Baciu, P.]]
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[[Category: Baciu P]]
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[[Category: Cech, T R.]]
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[[Category: Cech TR]]
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[[Category: Else, T.]]
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[[Category: Else T]]
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[[Category: Hammer, G D.]]
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[[Category: Hammer GD]]
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[[Category: Lei, M.]]
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[[Category: Lei M]]
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[[Category: Podell, E R.]]
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[[Category: Podell ER]]
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[[Category: Wang, F.]]
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[[Category: Wang F]]
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[[Category: Yang, Y T.]]
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[[Category: Yang YT]]
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[[Category: Zaug, A J.]]
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[[Category: Zaug AJ]]
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[[Category: Ob fold]]
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[[Category: Pot1 binding]]
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[[Category: Tpp1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 08:51:58 2008''
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Current revision

Crystal structure of human TPP1

PDB ID 2i46

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