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2i5c

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{{Seed}}
 
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[[Image:2i5c.png|left|200px]]
 
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<!--
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==Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5==
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The line below this paragraph, containing "STRUCTURE_2i5c", creates the "Structure Box" on the page.
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<StructureSection load='2i5c' size='340' side='right'caption='[[2i5c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2i5c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I5C FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IP5:(1R,2S,3R,4S,5S,6R)-6-HYDROXYCYCLOHEXANE-1,2,3,4,5-PENTAYL+PENTAKIS[DIHYDROGEN+(PHOSPHATE)]'>IP5</scene></td></tr>
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{{STRUCTURE_2i5c| PDB=2i5c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i5c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5c OCA], [https://pdbe.org/2i5c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i5c RCSB], [https://www.ebi.ac.uk/pdbsum/2i5c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i5c ProSAT]</span></td></tr>
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</table>
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===Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5===
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== Function ==
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[https://www.uniprot.org/uniprot/PLEK_HUMAN PLEK_HUMAN] Major protein kinase C substrate of platelets.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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The line below this paragraph, {{ABSTRACT_PUBMED_18034889}}, adds the Publication Abstract to the page
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Check<jmol>
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(as it appears on PubMed at http://www.pubmed.gov), where 18034889 is the PubMed ID number.
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i5/2i5c_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_18034889}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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2I5C is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I5C OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i5c ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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Structural analysis of the carboxy terminal PH domain of pleckstrin bound to D-myo-inositol 1,2,3,5,6-pentakisphosphate., Jackson SG, Zhang Y, Haslam RJ, Junop MS, BMC Struct Biol. 2007 Nov 22;7:80. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18034889 18034889]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Haslam, R J.]]
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[[Category: Haslam RJ]]
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[[Category: Jackson, S G.]]
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[[Category: Jackson SG]]
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[[Category: Junop, M S.]]
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[[Category: Junop MS]]
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[[Category: Lipid binding protein]]
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[[Category: Ph domain]]
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[[Category: Protein-inositol phosphate complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:49:13 2008''
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Current revision

Crystal structure of the C-terminal PH domain of pleckstrin in complex with D-myo-Ins(1,2,3,4,5)P5

PDB ID 2i5c

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