2i62

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[[Image:2i62.gif|left|200px]]
 
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{{Structure
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==Mouse Nicotinamide N-methyltransferase==
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|PDB= 2i62 |SIZE=350|CAPTION= <scene name='initialview01'>2i62</scene>, resolution 1.80&Aring;
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<StructureSection load='2i62' size='340' side='right'caption='[[2i62]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
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<table><tr><td colspan='2'>[[2i62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I62 FirstGlance]. <br>
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1] </span>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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|GENE= Nnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i62 OCA], [https://pdbe.org/2i62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i62 RCSB], [https://www.ebi.ac.uk/pdbsum/2i62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i62 ProSAT]</span></td></tr>
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|RELATEDENTRY=
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i62 OCA], [http://www.ebi.ac.uk/pdbsum/2i62 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i62 RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/NNMT_MOUSE NNMT_MOUSE] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
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== Evolutionary Conservation ==
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'''Mouse Nicotinamide N-methyltransferase'''
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i62_consurf.spt"</scriptWhenChecked>
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2I62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I62 OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i62 ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Nicotinamide N-methyltransferase]]
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[[Category: Arrowsmith CH]]
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[[Category: Single protein]]
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[[Category: Bochkarev A]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Edwards AM]]
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[[Category: Bochkarev, A.]]
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[[Category: Loppnau P]]
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[[Category: Edwards, A M.]]
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[[Category: Min J]]
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[[Category: Loppnau, P.]]
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[[Category: Plotnikov AN]]
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[[Category: Min, J.]]
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[[Category: Sundstrom M]]
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[[Category: Plotnikov, A N.]]
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[[Category: Weigelt J]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Wu H]]
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[[Category: Sundstrom, M.]]
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[[Category: Zeng H]]
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[[Category: Weigelt, J.]]
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[[Category: Wu, H.]]
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[[Category: Zeng, H.]]
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[[Category: nicotinamide n-methyltransferase]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:14 2008''
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Current revision

Mouse Nicotinamide N-methyltransferase

PDB ID 2i62

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