This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2i62

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:01, 21 February 2024) (edit) (undo)
 
(9 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2i62.gif|left|200px]]
 
-
{{Structure
+
==Mouse Nicotinamide N-methyltransferase==
-
|PDB= 2i62 |SIZE=350|CAPTION= <scene name='initialview01'>2i62</scene>, resolution 1.80&Aring;
+
<StructureSection load='2i62' size='340' side='right'caption='[[2i62]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>
+
<table><tr><td colspan='2'>[[2i62]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I62 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I62 FirstGlance]. <br>
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nicotinamide_N-methyltransferase Nicotinamide N-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.1 2.1.1.1] </span>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-
|GENE= Nnmt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
-
|DOMAIN=
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i62 OCA], [https://pdbe.org/2i62 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i62 RCSB], [https://www.ebi.ac.uk/pdbsum/2i62 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i62 ProSAT]</span></td></tr>
-
|RELATEDENTRY=
+
</table>
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i62 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i62 OCA], [http://www.ebi.ac.uk/pdbsum/2i62 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i62 RCSB]</span>
+
== Function ==
-
}}
+
[https://www.uniprot.org/uniprot/NNMT_MOUSE NNMT_MOUSE] Catalyzes the N-methylation of nicotinamide and other pyridines to form pyridinium ions. This activity is important for biotransformation of many drugs and xenobiotic compounds.
-
 
+
== Evolutionary Conservation ==
-
'''Mouse Nicotinamide N-methyltransferase'''
+
[[Image:Consurf_key_small.gif|200px|right]]
-
 
+
Check<jmol>
-
 
+
<jmolCheckbox>
-
==About this Structure==
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/2i62_consurf.spt"</scriptWhenChecked>
-
2I62 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I62 OCA].
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2i62 ConSurf].
 +
<div style="clear:both"></div>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
-
[[Category: Nicotinamide N-methyltransferase]]
+
[[Category: Arrowsmith CH]]
-
[[Category: Single protein]]
+
[[Category: Bochkarev A]]
-
[[Category: Arrowsmith, C H.]]
+
[[Category: Edwards AM]]
-
[[Category: Bochkarev, A.]]
+
[[Category: Loppnau P]]
-
[[Category: Edwards, A M.]]
+
[[Category: Min J]]
-
[[Category: Loppnau, P.]]
+
[[Category: Plotnikov AN]]
-
[[Category: Min, J.]]
+
[[Category: Sundstrom M]]
-
[[Category: Plotnikov, A N.]]
+
[[Category: Weigelt J]]
-
[[Category: SGC, Structural Genomics Consortium.]]
+
[[Category: Wu H]]
-
[[Category: Sundstrom, M.]]
+
[[Category: Zeng H]]
-
[[Category: Weigelt, J.]]
+
-
[[Category: Wu, H.]]
+
-
[[Category: Zeng, H.]]
+
-
[[Category: nicotinamide n-methyltransferase]]
+
-
[[Category: sgc]]
+
-
[[Category: structural genomic]]
+
-
[[Category: structural genomics consortium]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:14 2008''
+

Current revision

Mouse Nicotinamide N-methyltransferase

PDB ID 2i62

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i62"
Personal tools