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2ima

From Proteopedia

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{{Seed}}
 
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[[Image:2ima.png|left|200px]]
 
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==Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by 2,4-dichlorocinnamic hydroxamate==
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The line below this paragraph, containing "STRUCTURE_2ima", creates the "Structure Box" on the page.
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<StructureSection load='2ima' size='340' side='right'caption='[[2ima]], [[Resolution|resolution]] 1.94&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2ima]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IMA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2IMA FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.94&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GB4:(2E)-3-(2,4-DICHLOROPHENYL)-N-HYDROXYACRYLAMIDE'>GB4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2ima| PDB=2ima | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2ima FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ima OCA], [https://pdbe.org/2ima PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2ima RCSB], [https://www.ebi.ac.uk/pdbsum/2ima PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2ima ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q84GJ4_CLOBO Q84GJ4_CLOBO]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/im/2ima_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2ima ConSurf].
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<div style="clear:both"></div>
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===Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by 2,4-dichlorocinnamic hydroxamate===
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==See Also==
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*[[Botulinum neurotoxin 3D structures|Botulinum neurotoxin 3D structures]]
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__TOC__
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</StructureSection>
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The line below this paragraph, {{ABSTRACT_PUBMED_17524984}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 17524984 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17524984}}
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==About this Structure==
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2IMA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2IMA OCA].
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==Reference==
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Structures of Clostridium botulinum Neurotoxin Serotype A Light Chain complexed with small-molecule inhibitors highlight active-site flexibility., Silvaggi NR, Boldt GE, Hixon MS, Kennedy JP, Tzipori S, Janda KD, Allen KN, Chem Biol. 2007 May;14(5):533-42. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17524984 17524984]
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[[Category: Bontoxilysin]]
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[[Category: Clostridium botulinum]]
[[Category: Clostridium botulinum]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Allen, K N.]]
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[[Category: Allen KN]]
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[[Category: Silvaggi, N R.]]
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[[Category: Silvaggi NR]]
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[[Category: Clostridium botulinum neurotoxin serotype some]]
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[[Category: Protease inhibitor]]
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[[Category: Substrate specificity]]
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[[Category: Substrate switching]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:29:12 2008''
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Current revision

Clostridium botulinum Neurotoxin Serotype A Light Chain Inhibited by 2,4-dichlorocinnamic hydroxamate

PDB ID 2ima

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