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2p98

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[[Image:2p98.png|left|200px]]
 
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{{STRUCTURE_2p98| PDB=2p98 | SCENE= }}
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==E. coli methionine aminopeptidase monometalated with inhibitor YE7==
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<StructureSection load='2p98' size='340' side='right'caption='[[2p98]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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===E. coli methionine aminopeptidase monometalated with inhibitor YE7===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2p98]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P98 FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17948983}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=YE7:IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE'>YE7</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p98 OCA], [https://pdbe.org/2p98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p98 RCSB], [https://www.ebi.ac.uk/pdbsum/2p98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p98 ProSAT]</span></td></tr>
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[[2p98]] is a 1 chain structure of [[Aminopeptidase]] with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P98 OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MAP1_ECOLI MAP1_ECOLI] Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed.[HAMAP-Rule:MF_01974]<ref>PMID:20521764</ref> <ref>PMID:3027045</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p9/2p98_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p98 ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Aminopeptidase|Aminopeptidase]]
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*[[Aminopeptidase 3D structures|Aminopeptidase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:017948983</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Methionyl aminopeptidase]]
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[[Category: Large Structures]]
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[[Category: Ye, Q.]]
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[[Category: Ye Q]]
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[[Category: Enzyme-inhibitor complex]]
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[[Category: Hydrolase]]
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[[Category: Metalloenzyme]]
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[[Category: Monometalated]]
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[[Category: Mononuclear]]
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Current revision

E. coli methionine aminopeptidase monometalated with inhibitor YE7

PDB ID 2p98

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