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2pkt
From Proteopedia
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==Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1== | ==Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1== | ||
| - | <StructureSection load='2pkt' size='340' side='right' caption='[[2pkt]], [[Resolution|resolution]] 1.50Å' scene=''> | + | <StructureSection load='2pkt' size='340' side='right'caption='[[2pkt]], [[Resolution|resolution]] 1.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2pkt]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2pkt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2PKT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2PKT FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2pkt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2pkt OCA], [https://pdbe.org/2pkt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2pkt RCSB], [https://www.ebi.ac.uk/pdbsum/2pkt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2pkt ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PDLI1_HUMAN PDLI1_HUMAN] Cytoskeletal protein that may act as an adapter that brings other proteins (like kinases) to the cytoskeleton. |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/2pkt_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/pk/2pkt_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2pkt ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Group:MUZIC:ALP|MUZIC:ALP]] | ||
*[[PDZ and LIM domain protein|PDZ and LIM domain protein]] | *[[PDZ and LIM domain protein|PDZ and LIM domain protein]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Large Structures]] |
| - | [[Category: Bray | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bunkoczi | + | [[Category: Bray J]] |
| - | [[Category: Burgess-Brown | + | [[Category: Bunkoczi G]] |
| - | + | [[Category: Burgess-Brown N]] | |
| - | [[Category: Doyle | + | [[Category: Doyle DA]] |
| - | [[Category: Edwards | + | [[Category: Edwards A]] |
| - | [[Category: Elkins | + | [[Category: Elkins J]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi C]] |
| - | [[Category: Gileadi | + | [[Category: Gileadi O]] |
| - | + | [[Category: Salah E]] | |
| - | [[Category: Salah | + | [[Category: Sundstrom M]] |
| - | [[Category: Sundstrom | + | [[Category: Ugochukwu E]] |
| - | [[Category: Ugochukwu | + | [[Category: Umeano C]] |
| - | [[Category: Umeano | + | [[Category: Uppenberg J]] |
| - | [[Category: Uppenberg | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Von Delft F]] |
| - | [[Category: | + | |
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the human CLP-36 (PDLIM1) bound to the C-terminal peptide of human alpha-actinin-1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bray J | Bunkoczi G | Burgess-Brown N | Doyle DA | Edwards A | Elkins J | Gileadi C | Gileadi O | Salah E | Sundstrom M | Ugochukwu E | Umeano C | Uppenberg J | Weigelt J | Von Delft F
