2q3g

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[[Image:2q3g.jpg|left|200px]]
 
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{{Structure
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==Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin==
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|PDB= 2q3g |SIZE=350|CAPTION= <scene name='initialview01'>2q3g</scene>, resolution 1.11&Aring;
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<StructureSection load='2q3g' size='340' side='right'caption='[[2q3g]], [[Resolution|resolution]] 1.11&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>
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<table><tr><td colspan='2'>[[2q3g]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3G FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.11&#8491;</td></tr>
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|GENE= PDLIM7 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
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|DOMAIN=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3g OCA], [https://pdbe.org/2q3g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3g RCSB], [https://www.ebi.ac.uk/pdbsum/2q3g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3g ProSAT]</span></td></tr>
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|RELATEDENTRY=[[2q3h|2Q3H]]
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</table>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q3g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3g OCA], [http://www.ebi.ac.uk/pdbsum/2q3g PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q3g RCSB]</span>
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== Function ==
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}}
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[https://www.uniprot.org/uniprot/PDLI7_HUMAN PDLI7_HUMAN] May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity).<ref>PMID:7929196</ref> <ref>PMID:11874232</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3g_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3g ConSurf].
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<div style="clear:both"></div>
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'''Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin'''
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==See Also==
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*[[PDZ and LIM domain protein|PDZ and LIM domain protein]]
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== References ==
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==About this Structure==
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<references/>
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2Q3G is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3G OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith, C H.]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi, G.]]
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[[Category: Bunkoczi G]]
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[[Category: Burgess-Brown, N.]]
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[[Category: Burgess-Brown N]]
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[[Category: Delft, F von.]]
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[[Category: Doyle DA]]
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[[Category: Doyle, D A.]]
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[[Category: Edwards A]]
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[[Category: Edwards, A.]]
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[[Category: Elkins J]]
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[[Category: Elkins, J.]]
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[[Category: Gileadi C]]
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[[Category: Gileadi, C.]]
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[[Category: Gileadi O]]
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[[Category: Gileadi, O.]]
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[[Category: Papagrigoriou E]]
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[[Category: Papagrigoriou, E.]]
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[[Category: Pike ACW]]
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[[Category: Pike, A C.W.]]
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[[Category: Salah E]]
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[[Category: SGC, Structural Genomics Consortium.]]
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[[Category: Sundstrom M]]
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[[Category: Salah, E.]]
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[[Category: Umeano C]]
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[[Category: Sundstrom, M.]]
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[[Category: Uppenberg J]]
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[[Category: Umeano, C.]]
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[[Category: Weigelt J]]
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[[Category: Uppenberg, J.]]
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[[Category: Von Delft F]]
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[[Category: Weigelt, J.]]
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[[Category: sgc]]
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[[Category: structural genomic]]
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[[Category: structural genomics consortium]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:44:03 2008''
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Current revision

Structure of the PDZ domain of human PDLIM7 bound to a C-terminal extension from human beta-tropomyosin

PDB ID 2q3g

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OCA

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