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2q3y

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{{Seed}}
 
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[[Image:2q3y.png|left|200px]]
 
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==Ancestral Corticiod Receptor in Complex with DOC==
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The line below this paragraph, containing "STRUCTURE_2q3y", creates the "Structure Box" on the page.
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<StructureSection load='2q3y' size='340' side='right'caption='[[2q3y]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q3y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q3Y FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1CA:DESOXYCORTICOSTERONE'>1CA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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{{STRUCTURE_2q3y| PDB=2q3y | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q3y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q3y OCA], [https://pdbe.org/2q3y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q3y RCSB], [https://www.ebi.ac.uk/pdbsum/2q3y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q3y ProSAT]</span></td></tr>
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</table>
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===Ancestral Corticiod Receptor in Complex with DOC===
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== Disease ==
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[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Defects in NR0B2 may be associated with obesity (OBESITY) [MIM:[https://omim.org/entry/601665 601665]. It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.<ref>PMID:11136233</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/NR0B2_HUMAN NR0B2_HUMAN] Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated trancription complex for NEUROD1.<ref>PMID:14752053</ref>
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The line below this paragraph, {{ABSTRACT_PUBMED_17702911}}, adds the Publication Abstract to the page
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== Evolutionary Conservation ==
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(as it appears on PubMed at http://www.pubmed.gov), where 17702911 is the PubMed ID number.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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{{ABSTRACT_PUBMED_17702911}}
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q3/2q3y_consurf.spt"</scriptWhenChecked>
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==About this Structure==
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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2Q3Y is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Unidentified Unidentified]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q3Y OCA].
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==Reference==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q3y ConSurf].
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Crystal structure of an ancient protein: evolution by conformational epistasis., Ortlund EA, Bridgham JT, Redinbo MR, Thornton JW, Science. 2007 Sep 14;317(5844):1544-8. Epub 2007 Aug 16. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17702911 17702911]
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<div style="clear:both"></div>
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[[Category: Single protein]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
[[Category: Unidentified]]
[[Category: Unidentified]]
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[[Category: Bridgham, J T.]]
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[[Category: Bridgham JT]]
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[[Category: Ortlund, E A.]]
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[[Category: Ortlund EA]]
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[[Category: Redinbo, M R.]]
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[[Category: Redinbo MR]]
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[[Category: Thornton, J W.]]
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[[Category: Thornton JW]]
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[[Category: Cortisol]]
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[[Category: Doc]]
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[[Category: Evolution]]
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[[Category: Ligand binding domain]]
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[[Category: Mineralocoticiod]]
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[[Category: Nuclear receptor]]
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[[Category: Transcription]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:30:06 2008''
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Current revision

Ancestral Corticiod Receptor in Complex with DOC

PDB ID 2q3y

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