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2q7z

From Proteopedia

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(New page: 200px<br /> <applet load="2q7z" size="450" color="white" frame="true" align="right" spinBox="true" caption="2q7z" /> '''Solution Structure of the 30 SCR domains of...)
Current revision (09:14, 21 February 2024) (edit) (undo)
 
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[[Image:2q7z.gif|left|200px]]<br />
 
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<applet load="2q7z" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2q7z" />
 
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'''Solution Structure of the 30 SCR domains of human Complement Receptor 1'''<br />
 
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==Disease==
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==Solution Structure of the 30 SCR domains of human Complement Receptor 1==
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Known diseases associated with this structure: Blood group, Knops system OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], CR1 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], Malaria, severe, resistance to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]], SLE susceptibility OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=120620 120620]]
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<StructureSection load='2q7z' size='340' side='right'caption='[[2q7z]]' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[2q7z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q7Z FirstGlance]. <br>
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2Q7Z is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2Q7Z OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray solution scattering</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q7z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q7z OCA], [https://pdbe.org/2q7z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q7z RCSB], [https://www.ebi.ac.uk/pdbsum/2q7z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q7z ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CR1_HUMAN CR1_HUMAN] Mediates cellular binding of particles and immune complexes that have activated complement.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q7/2q7z_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q7z ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Furtado, P.B.]]
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[[Category: Furtado PB]]
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[[Category: Hammond, R.A.]]
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[[Category: Hammond RA]]
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[[Category: Huang, C.Y.]]
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[[Category: Huang CY]]
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[[Category: Ihyembe, D.]]
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[[Category: Ihyembe D]]
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[[Category: Marsh, H.C.]]
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[[Category: Marsh HC]]
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[[Category: Perkins, S.J.]]
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[[Category: Perkins SJ]]
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[[Category: blood group antigen]]
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[[Category: complement]]
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[[Category: complement pathway]]
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[[Category: glycoprotein]]
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[[Category: immune response]]
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[[Category: immune system]]
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[[Category: innate immunity]]
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[[Category: membrane]]
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[[Category: polymorphism]]
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[[Category: pyrrolidone carboxylic acid]]
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[[Category: receptor]]
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[[Category: scr domain]]
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[[Category: sushi]]
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[[Category: transmembrane]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:30:49 2007''
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Current revision

Solution Structure of the 30 SCR domains of human Complement Receptor 1

PDB ID 2q7z

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