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2q9q

From Proteopedia

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{{Seed}}
 
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[[Image:2q9q.png|left|200px]]
 
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<!--
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==The crystal structure of full length human GINS complex==
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The line below this paragraph, containing "STRUCTURE_2q9q", creates the "Structure Box" on the page.
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<StructureSection load='2q9q' size='340' side='right'caption='[[2q9q]], [[Resolution|resolution]] 2.36&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2q9q]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Q9Q FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.36&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2q9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q9q OCA], [https://pdbe.org/2q9q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2q9q RCSB], [https://www.ebi.ac.uk/pdbsum/2q9q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2q9q ProSAT]</span></td></tr>
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{{STRUCTURE_2q9q| PDB=2q9q | SCENE= }}
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</table>
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== Function ==
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===The crystal structure of full length human GINS complex===
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[https://www.uniprot.org/uniprot/PSF2_HUMAN PSF2_HUMAN] The GINS complex plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.<ref>PMID:17417653</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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<!--
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_17652513}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 17652513 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/q9/2q9q_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_17652513}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2q9q ConSurf].
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2Q9Q is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Q9Q OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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Crystal structure of the GINS complex and functional insights into its role in DNA replication., Chang YP, Wang G, Bermudez V, Hurwitz J, Chen XS, Proc Natl Acad Sci U S A. 2007 Jul 31;104(31):12685-90. Epub 2007 Jul 25. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17652513 17652513]
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Protein complex]]
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[[Category: Large Structures]]
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[[Category: Chang, Y P.]]
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[[Category: Chang YP]]
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[[Category: Chen, X S.]]
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[[Category: Chen XS]]
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[[Category: Wang, G.]]
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[[Category: Wang G]]
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[[Category: Elongated spindle]]
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[[Category: Helix bundle]]
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[[Category: Replication]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:44:18 2008''
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Current revision

The crystal structure of full length human GINS complex

PDB ID 2q9q

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