2qbz

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==Structure of the M-Box Riboswitch Aptamer Domain==
==Structure of the M-Box Riboswitch Aptamer Domain==
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<StructureSection load='2qbz' size='340' side='right' caption='[[2qbz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
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<StructureSection load='2qbz' size='340' side='right'caption='[[2qbz]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qbz]] is a 1 chain structure. The October 2010 RCSB PDB [http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Riboswitches'' by David Goodsell is [http://dx.doi.org/10.2210/rcsb_pdb/mom_2010_10 10.2210/rcsb_pdb/mom_2010_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBZ OCA]. <br>
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<table><tr><td colspan='2'>[[2qbz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. The October 2010 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''Riboswitches'' by David Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2010_10 10.2210/rcsb_pdb/mom_2010_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QBZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QBZ FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glucokinase Glucokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.2 2.7.1.2] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qbz OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2qbz RCSB], [http://www.ebi.ac.uk/pdbsum/2qbz PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qbz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qbz OCA], [https://pdbe.org/2qbz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qbz RCSB], [https://www.ebi.ac.uk/pdbsum/2qbz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qbz ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Organisms maintain the correct balance of intracellular metals primarily through metal-sensing proteins that control transport and storage of the target ion(s). Here, we reveal the basis of metal sensing and genetic control by a metalloregulatory RNA. Our data demonstrate that a previously uncharacterized orphan riboswitch, renamed the "M-box," is a divalent metal-sensing RNA involved in Mg(2+) homeostasis. A combination of genetic, biochemical, and biophysical techniques demonstrate that Mg(2+) induces a compacted tertiary architecture for M-box RNAs that regulates the accessibility of nucleotides involved in genetic control. Molecular details are provided by crystallographic structure determination of a Mg(2+)-bound M-box RNA. Given the distribution of this RNA element, it may constitute a common mode for bacterial metal ion regulation, and its discovery suggests the possibility of additional RNA-based metal sensors in modern and primordial organisms.
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Structure and mechanism of a metal-sensing regulatory RNA.,Dann CE 3rd, Wakeman CA, Sieling CL, Baker SC, Irnov I, Winkler WC Cell. 2007 Sep 7;130(5):878-92. PMID:17803910<ref>PMID:17803910</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus subtilis]]
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[[Category: Large Structures]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Riboswitches]]
[[Category: Riboswitches]]
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[[Category: III, C E.Dann.]]
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[[Category: Dann III CE]]
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[[Category: Winkler, W C.]]
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[[Category: Winkler WC]]
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[[Category: M-box]]
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[[Category: Noncoding rna]]
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[[Category: Riboswitch]]
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[[Category: Rna]]
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[[Category: Rna sensor]]
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[[Category: Ykok]]
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Current revision

Structure of the M-Box Riboswitch Aptamer Domain

PDB ID 2qbz

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