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2qmp

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==Crystal Structure of HIV-1 protease complexed with PL-100==
==Crystal Structure of HIV-1 protease complexed with PL-100==
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<StructureSection load='2qmp' size='340' side='right' caption='[[2qmp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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<StructureSection load='2qmp' size='340' side='right'caption='[[2qmp]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2qmp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QMP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2QMP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2qmp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_immunodeficiency_virus_1 Human immunodeficiency virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QMP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QMP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A00:N-[(5S)-5-{[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO}-6-HYDROXYHEXYL]-NALPHA-(METHOXYCARBONYL)-BETA-PHENYL-L-PHENYLALANINAMIDE'>A00</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A00:N-[(5S)-5-{[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO}-6-HYDROXYHEXYL]-NALPHA-(METHOXYCARBONYL)-BETA-PHENYL-L-PHENYLALANINAMIDE'>A00</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qmp OCA], [http://pdbe.org/2qmp PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2qmp RCSB], [http://www.ebi.ac.uk/pdbsum/2qmp PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qmp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qmp OCA], [https://pdbe.org/2qmp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qmp RCSB], [https://www.ebi.ac.uk/pdbsum/2qmp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qmp ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q9WFL7_9HIV1 Q9WFL7_9HIV1]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qmp_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qm/2qmp_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: HIV-1 retropepsin]]
 
[[Category: Human immunodeficiency virus 1]]
[[Category: Human immunodeficiency virus 1]]
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[[Category: Allison, T J]]
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[[Category: Large Structures]]
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[[Category: Aspartyl protease]]
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[[Category: Allison TJ]]
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[[Category: Hiv-1 protease]]
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[[Category: Hydrolase]]
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[[Category: Multifunctional enzyme]]
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[[Category: Nucleotidyltransferase]]
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[[Category: Rna-directed dna polymerase]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of HIV-1 protease complexed with PL-100

PDB ID 2qmp

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