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2qnc

From Proteopedia

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[[Image:2qnc.png|left|200px]]
 
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{{STRUCTURE_2qnc| PDB=2qnc | SCENE= }}
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==Crystal structure of T4 Endonuclease VII N62D mutant in complex with a DNA Holliday junction==
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<StructureSection load='2qnc' size='340' side='right'caption='[[2qnc]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
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===Crystal structure of T4 Endonuclease VII N62D mutant in complex with a DNA Holliday junction===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2qnc]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QNC FirstGlance]. <br>
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{{ABSTRACT_PUBMED_17873859}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qnc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qnc OCA], [https://pdbe.org/2qnc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qnc RCSB], [https://www.ebi.ac.uk/pdbsum/2qnc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qnc ProSAT]</span></td></tr>
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[[2qnc]] is a 6 chain structure of [[Endonuclease]] with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_t4 Enterobacteria phage t4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QNC OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/END7_BPT4 END7_BPT4] Cleaves DNA cruciform and Y-structures as well as heteroduplex loops. Resolves Holliday junctions, recognizes a broad spectrum of DNA substrates ranging from branched DNAs to single base mismatches.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qn/2qnc_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qnc ConSurf].
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<div style="clear:both"></div>
==See Also==
==See Also==
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*[[Endonuclease|Endonuclease]]
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*[[Endonuclease 3D structures|Endonuclease 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:017873859</ref><references group="xtra"/>
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[[Category: Escherichia virus T4]]
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[[Category: Crossover junction endodeoxyribonuclease]]
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[[Category: Large Structures]]
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[[Category: Enterobacteria phage t4]]
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[[Category: Biertumpfel C]]
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[[Category: Biertumpfel, C.]]
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[[Category: Suck D]]
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[[Category: Suck, D.]]
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[[Category: Yang W]]
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[[Category: Yang, W.]]
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[[Category: Alternative initiation]]
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[[Category: Endo vii]]
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[[Category: Four-way junction]]
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[[Category: Holliday junction]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Metal-binding]]
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[[Category: Resolvase]]
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[[Category: Resolving-enzyme]]
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[[Category: T4 endonuclease vii]]
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Current revision

Crystal structure of T4 Endonuclease VII N62D mutant in complex with a DNA Holliday junction

PDB ID 2qnc

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