This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2qpw
From Proteopedia
(Difference between revisions)
| (13 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | [[Image:2qpw.jpg|left|200px]]<br /><applet load="2qpw" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2qpw, resolution 1.79Å" /> | ||
| - | '''Methyltransferase domain of human PR domain-containing protein 2'''<br /> | ||
| - | == | + | ==Methyltransferase domain of human PR domain-containing protein 2== |
| - | + | <StructureSection load='2qpw' size='340' side='right'caption='[[2qpw]], [[Resolution|resolution]] 1.79Å' scene=''> | |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2qpw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QPW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QPW FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.79Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qpw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qpw OCA], [https://pdbe.org/2qpw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qpw RCSB], [https://www.ebi.ac.uk/pdbsum/2qpw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qpw ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PRDM2_HUMAN PRDM2_HUMAN] S-adenosyl-L-methionine-dependent histone methyltransferase that specifically methylates 'Lys-9' of histone H3. May function as a DNA-binding transcription factor. Binds to the macrophage-specific TPA-responsive element (MTE) of the HMOX1 (heme oxygenase 1) gene and may act as a transcriptional activator of this gene.<ref>PMID:14633678</ref> | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qp/2qpw_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qpw ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Antoshenko | + | [[Category: Antoshenko T]] |
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Bochkarev | + | [[Category: Bochkarev A]] |
| - | [[Category: Dombrovski | + | [[Category: Dombrovski L]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Loppnau | + | [[Category: Loppnau P]] |
| - | [[Category: Lunin | + | [[Category: Lunin VV]] |
| - | [[Category: Min | + | [[Category: Min J]] |
| - | [[Category: Plotnikov | + | [[Category: Plotnikov AN]] |
| - | + | [[Category: Sundstrom M]] | |
| - | [[Category: Sundstrom | + | [[Category: Weigelt J]] |
| - | [[Category: Weigelt | + | [[Category: Wu H]] |
| - | [[Category: Wu | + | |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Methyltransferase domain of human PR domain-containing protein 2
| |||||||||||
Categories: Homo sapiens | Large Structures | Antoshenko T | Arrowsmith CH | Bochkarev A | Dombrovski L | Edwards AM | Loppnau P | Lunin VV | Min J | Plotnikov AN | Sundstrom M | Weigelt J | Wu H
